{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:05:35Z","timestamp":1785283535067,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T00:00:00Z","timestamp":1331596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p><jats:bold>Abstract\u2002\u2013\u2002<\/jats:bold> Dental tissues have special characteristics, and its regenerative capacity is noteworthy. However, understanding the circumstances that lead to regeneration is challenging. In this study, the chronology of the healing process after immediate replantation of rat incisor teeth was examined by histological and immunohistochemical analyses within a 60\u2010day period. Thirty\u2010six male Wistar rats had their maxillary right incisors extracted and replanted after 15\u2003min in saline storage. The rats were sacrificed immediately 3, 7, 15, 28, and 60\u2003days after replantation. The histological analysis showed rupture of the periodontal ligament and formation of a blood clot, which started being replaced by a connective tissue after 3\u2003days. At 7\u2003days, the gingival mucosa epithelium was reinserted and areas of root resorption could be seen. At 15\u2003days, the periodontal ligament was repaired. At 3\u2003days, the pulp presented an absence of the odontoblast layer, which started being replaced by a connective tissue. This tissue suffered gradual calcification, filling the root canal at 28 and 60\u2003days. The root ends were closed. The immunohistochemical analysis revealed greater expression of OP, OPG, and RANK proteins in the initial periods (0 and 3\u2003days), while TRAP expression predominated at 28 and 60\u2003days (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). In conclusion, in delayed tooth replantation, there is great new bone formation activity in the earlier periods of the repair process, while a predominance of bone resorption and remodeling is observed in the more advanced periods.<\/jats:p>","DOI":"10.1111\/j.1600-9657.2012.01127.x","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T03:14:24Z","timestamp":1331694864000},"page":"15-22","source":"Crossref","is-referenced-by-count":24,"title":["Histological and immunohistochemical analyses of the chronology of healing process after immediate tooth replantation in incisor rat teeth"],"prefix":"10.1111","volume":"29","author":[{"given":"S\u00f4nia Regina","family":"Panzarini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson Roberto","family":"Poi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Koogi","family":"Sonoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Pedrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Ervolino","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia Tomiko Matida Hamata","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helo\u00edsa Fonseca","family":"Mar\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Sedlacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,13]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Textbook and color atlas of traumatic injuries to the teeth","author":"Andreasen JO","year":"2007"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81569-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/36593"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00214-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2008.02.004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2010.00946.x"},{"key":"e_1_2_6_8_2","first-page":"499","article-title":"Tartrate\u2010resistant acid phosphatase 5b (TRACP5b) as a marker of bone resorption","volume":"52","author":"Halleen JM","year":"2006","journal-title":"Clin Lab"},{"key":"e_1_2_6_9_2","volume-title":"OPG, RANK and RANKL immunostaining in replanted rat teeth","author":"Manfrin TM","year":"2007"},{"key":"e_1_2_6_10_2","volume-title":"Resorption dent\u00e1ria nas especialidades cl\u00ednicas","author":"Consolaro A","year":"2005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.23.8819"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240106.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-2086-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.01636.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00699.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2003.00051.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01594.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/18.12.901"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02411252"},{"key":"e_1_2_6_20_2","first-page":"1325","article-title":"Interaction between osteoblast and osteoclast: impact in bone disease","volume":"19","author":"Phan TCA","year":"2004","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-003-0753-x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2004.03.038"},{"key":"e_1_2_6_23_2","first-page":"9","article-title":"Tooth resorption","volume":"30","author":"Ne RF","year":"1999","journal-title":"Quintessence Int"}],"container-title":["Dental Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-9657.2012.01127.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-9657.2012.01127.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T09:21:26Z","timestamp":1697620886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-9657.2012.01127.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,13]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1600-9657.2012.01127.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-9657.2012.01127.x","archive":["Portico"],"relation":{},"ISSN":["1600-4469","1600-9657"],"issn-type":[{"value":"1600-4469","type":"print"},{"value":"1600-9657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,13]]}}}