{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:02:15Z","timestamp":1774681335369,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":2796,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p>OBJECTIVE: The distribution and biological roles of interleukin (IL)\u20101\u03b2, IL\u20106, and tissue inhibitor of metalloproteinase\u20101 (TIMP\u20101) in the synovial fluid of patients with non\u2010inflammatory chronic temporomandibular joint (TMJ) disorders were evaluated in relation to pain upon joint movements and X\u2010ray and magnetic resonance imaging (MRI) findings.<\/jats:p><jats:p>MATERIALS AND METHODS: TMJ aspirates were obtained from 48 patients (48 joints) with chronic TMJ disorders and from 18 controls (18 joints). The IL\u20101\u03b2 and IL\u20106 levels in the aspirates were determined by using an enzyme\u2010linked immunosorbent assay and the TIMP\u20101 level was measured by an enzyme immunoassay. Following examinations for pain upon joint movements and X\u2010ray and MRI observations, the IL\u20101\/J, IL\u20106, and TIMP\u20101 levels and frequencies of their detection were compared.<\/jats:p><jats:p>RESULTS: The IL\u20101\u03b2 level and frequency of detection showed no correlation with pain upon joint movements or with the X\u2010ray and MRI findings. In the frequency of detection of IL\u20106, there were significant differences between control (no detection) and all chronic TMJ disorder groups that were classified by imaging diagnosis (<jats:italic>P<\/jats:italic> &lt; 0.001). A correlation was also noted between the presence of IL\u20106 and pain upon joint movements. The IL\u20106 level was correlated with the TIMP\u20101 level and with pain upon joint movements. TIMP\u20101 level was correlated with pain upon joint movements. The TIMP\u20101 was present in higher level from patients with chronic TMJ disorders who exhibited osseous changes on the X\u2010ray images. CONCLUSION: The results indicated that the IL\u20106 and TIMP\u20101 levels in the TMJ aspirates of patients with chronic TMJ disorders have been raised. The former was not detected in the TMJ aspirates of the control. These findings suggest that IL\u20106 and TIMP\u20101 might play a role in the etiology of chronic TMJ disorders, but further studies are needed to validate this.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2000.tb00131.x","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T11:11:41Z","timestamp":1280833901000},"page":"383-390","source":"Crossref","is-referenced-by-count":43,"title":["Oral and Maxillofacial Pathology: Interleukin\u20101 \u03b2, interleukin\u20106, and tissue inhibitor of metalloproteinase\u20101 in the synovial fluid of the temporomandibular joint with respect to cartilage destruction"],"prefix":"10.1111","volume":"6","author":[{"given":"C","family":"Shinoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Takaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-4356(97)90555-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1995.tb00162.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(98)90256-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90085-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01986402"},{"key":"e_1_2_1_7_1","first-page":"589","volume-title":"Proteinase Inhibitors","author":"Cawston TE","year":"1986"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009749209095081"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541245"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(95)90717-3"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113135"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80015-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-4356(98)90745-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.4049\/jimmunol.147.7.2181","article-title":"Release of IL\u20101 from mononuclear phagocytes","volume":"147","author":"Hogquist KA","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_1_15_1","first-page":"422","article-title":"Cytokines in synovial fluid I. 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