{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:24:28Z","timestamp":1759602268901},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T00:00:00Z","timestamp":1086912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> Knowledge of the molecular pathogenesis of oral submucous fibrosis (OSF), a potentially malignant condition with high risk of transition to oral cancer, is meagre. Alterations in the expression of retinoic acid receptor <jats:italic>\u03b2<\/jats:italic> (RAR<jats:italic>\u03b2<\/jats:italic>) and tumor suppressor gene, p53 are early events in oral tumorigenesis. The aim of this study was to investigate the alterations in the expression of RAR<jats:italic>\u03b2<\/jats:italic> and p53 in OSF lesions and determine their association with disease pathogenesis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The expression of RAR<jats:italic>\u03b2<\/jats:italic> and p53 proteins was analyzed by immunohistochemistry in 50 cases of OSF and 30 histologically normal oral tissues.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> No detectable RAR<jats:italic>\u03b2<\/jats:italic> expression was observed in 35 of 50 (70%) OSF cases. p53 protein accumulation was observed in 24 of 50 (48%) OSF cases analyzed. Thirty\u2010six percent OSF lesions showed loss of RAR<jats:italic>\u03b2<\/jats:italic> and p53 overexpression. Interestingly, 41 of 50 (82%) of OSF lesions showed altered expression of at least one of these two proteins.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Altered expression of either RAR<jats:italic>\u03b2<\/jats:italic> or p53 in majority of OSF lesions suggests their association with disease pathogenesis and warrants follow\u2010up to determine whether OSF lesions harboring concomitant alterations in RAR<jats:italic>\u03b2<\/jats:italic> and p53 are at a high risk of transition to malignancy.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2004.00993.x","type":"journal-article","created":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T12:36:46Z","timestamp":1086957406000},"page":"201-206","source":"Crossref","is-referenced-by-count":5,"title":["Alterations in expression of retinoid receptor <i>\u03b2<\/i> and p53 in oral submucous 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