{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:00:23Z","timestamp":1778133623015,"version":"3.51.4"},"reference-count":69,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T00:00:00Z","timestamp":1099612800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To determine point and annual prevalence of recurrent aphthous stomatitis (RAS).<\/jats:p><jats:p><jats:bold>Setting:\u2002<\/jats:bold> Reported prevalence of RAS in textbooks and much of the literature varies according to study location, patient selection and whether point prevalence (presence of lesions at examination) or period prevalence (history of lesions during a specified period) is reported. Many studies are based on non\u2010probability samples and this may contribute to significant variation in reported prevalence and factors presumed to be associated with RAS.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We analyzed data from the Third National Health and Nutrition Examination Survey, 1988\u20131994, a large United States probability sample, for RAS and covariates suggested in the literature using bivariate and multivariate logistic regression.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Oral mucosal examinations were performed on 17\u2003235 adults 17\u2003years and older. Of these, 146 (0.89%) had at least one clinically apparent aphthous lesion. For annual (reported) prevalence, Whites (20.87%) and Mexican\u2010Americans (12.88%) had several fold higher prevalence of RAS than Blacks (4.96%). Adults younger than 40\u2003years of age had almost twice the prevalence (22.54%) of those older than 40\u2003years (13.42%).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Annual prevalence was significantly higher in whites and Mexican\u2010Americans (compared with blacks), individuals 17\u201339\u2003years of age, cigarette non\u2010smokers, and those with recurrent herpes labialis history; while it was lower in males. Point prevalence was significantly higher in whites, Mexican\u2010American, individuals 17\u201339\u2003years of age, cigarette non\u2010smokers, and males.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2004.01049.x","type":"journal-article","created":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T14:11:50Z","timestamp":1099663910000},"page":"335-345","source":"Crossref","is-referenced-by-count":55,"title":["The association of tobacco and other factors with recurrent aphthous stomatitis in an US adult population"],"prefix":"10.1111","volume":"10","author":[{"given":"F","family":"Rivera\u2010Hidalgo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JD","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MM","family":"Beach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,5]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)80170-0"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.01826.x"},{"key":"e_1_2_20_4_1","first-page":"1","article-title":"A prevalence study of oral mucosal lesions in an adult Swedish population","volume":"27","author":"Ax\u00e9ll T","year":"1976","journal-title":"Odontol Revy"},{"key":"e_1_2_20_5_1","first-page":"239","article-title":"Association between recurrent aphthous ulcers and tobacco habits","volume":"93","author":"Ax\u00e9ll T","year":"1985","journal-title":"Scand J Dent Res"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016358509046497"},{"key":"e_1_2_20_7_1","first-page":"85","article-title":"Hematologic deficiencies in patients with recurrent oral aphthae","volume":"109","author":"Barnadas MA","year":"1997","journal-title":"Med Clin (Barc)"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X97221485"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0438019100"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02024.x"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1991.tb121180.x"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199504000-00009"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1983.tb00339.x"},{"issue":"5","key":"e_1_2_20_14_1","first-page":"S31","article-title":"HLA\u2010B51 and its allelic types in association with Behcet's disease and recurrent aphthous stomatitis in Korea","volume":"19","author":"Chang HK","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00330-5"},{"key":"e_1_2_20_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199811000-00006"},{"key":"e_1_2_20_17_1","first-page":"75","article-title":"Lesions of the oral mucosa. 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