{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:54:13Z","timestamp":1761512053945},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T00:00:00Z","timestamp":1221523200000},"content-version":"vor","delay-in-days":1295,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> Acute and chronic actions of lithium on salivation induced by agonists associated with receptor\u2010linked hydrolysis of membrane inositol phospholipids (carbachol and phenylephrine) and by agonist linked to activation of adenylate cyclase (isoproterenol) were investigated.<\/jats:p><jats:p><jats:bold>Material and methods:\u2002<\/jats:bold> In anaesthetized rats, submandibular salivation induced by intravenous injection of carbachol, phenylephrine and isoproterenol, was measured and expressed as volume of fluid (<jats:italic>\u03bc<\/jats:italic>l) elicited per 100\u2003mg wet weight of each gland per minute. The experiments were repeated after acute and chronic treatment of lithium (7\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>). The results were analysed with unpaired <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Chronic, but not acute lithium treatment significantly decreases carbachol\u2010 and phenylephrine\u2010induced salivation while isoproterenol\u2010induced salivation was not changed neither after acute nor after chronic administration of lithium.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results suggest that hyposalivation during chronic lithium therapy could be mediated by alterations in the phosphatidylinositol cycle and a consequent lack of inositol after agonist stimulation.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2004.01066.x","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T08:58:32Z","timestamp":1109926712000},"page":"100-103","source":"Crossref","is-referenced-by-count":6,"title":["The effects of acute and chronic lithium treatment on rat submandibular 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