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The present study was undertaken to identify and quantify the presence of mast cells in different stages of human periodontal disease using histochemical (toluidine blue) and immunohistochemical (tryptase\u2010positive mast cells) techniques.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Mast cell densities (cells per mm<jats:sup>2<\/jats:sup>) were significantly increased in chronic periodontitis\/gingivitis lesions compared with clinically healthy gingival tissues (Health) uniquely by immunohistochemical technique. Interestingly, mast cells were distributed specially in close apposition to mononuclear cells.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In human periodontal disease there is an increase in the number of mast cells that may be participating either in the destructive events or in the defense mechanism of periodontal disease via secretion of cytokines, including perpetuation of the Th2 response, and cellular migration and healing processes.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2005.01113.x","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T16:42:42Z","timestamp":1119976962000},"page":"249-254","source":"Crossref","is-referenced-by-count":44,"title":["Quantification of mast cells in different stages of human periodontal 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