{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:40:12Z","timestamp":1696977612931},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> In HIV+ persons with reduced CD4<jats:sup>+<\/jats:sup> T cells, oropharyngeal candidiasis (OPC) is often associated with the accumulation of CD8<jats:sup>+<\/jats:sup> T cells at the epithelial\/lamina propria interface within the lesion together with increased tissue\u2010associated cytokines and chemokines. Despite this reactivity, a dysfunction in the ability of the CD8<jats:sup>+<\/jats:sup> cells to reach the organism at the outer epithelium is postulated. The purpose of this study was to examine chemokine receptors present in the OPC lesions for a potential role in susceptibility to infection.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Biopsies taken from buccal mucosa of HIV\u2212 persons, healthy mucosa of HIV+ OPC\u2212 persons, and OPC lesions were processed for protein immunohistochemical staining or RNA analysis by real\u2010time PCR and Superarray.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There was little change in expression of chemokine receptors at the protein or RNA level between OPC+ and OPC\u2212 tissue. At the protein level, increases occurred in OPC+ persons only if associated with CD8 cells. In the Superarray, of the 22 chemokine receptor mRNAs expressed, <jats:italic>c.<\/jats:italic> 90% remained unchanged (&lt;1.0\u2010fold change) between HIV\u2212 and HIV+ tissue and between HIV+ OPC\u2212 and HIV+ OPC+ tissue.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Tissue\u2010associated chemokine receptor expression does not appear to contribute to the dysfunction in cellular migration associated with susceptibility to OPC.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2006.01226.x","type":"journal-article","created":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T07:42:11Z","timestamp":1153381331000},"page":"493-499","source":"Crossref","is-referenced-by-count":2,"title":["Chemokine receptor expression in HIV\u2010positive persons with oropharyngeal candidiasis"],"prefix":"10.1111","volume":"12","author":[{"given":"EA","family":"Lilly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JE","family":"Leigh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KM","family":"McNulty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SH","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DE","family":"Mercante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"PL","family":"Fidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Candida and candidiasis","author":"Calderone RA","year":"2002"},{"key":"e_1_2_6_3_1","first-page":"34","article-title":"Candidiasis in the transplant patient","volume":"77","author":"Clift RA","year":"1984","journal-title":"Am J Med"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199111000-00009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.06.040"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/313765"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90185-S"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300504"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408093110602"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/123.4.371"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb00994.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/317944"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/422154"},{"key":"e_1_2_6_14_1","first-page":"246","article-title":"The pathology of AIDS","volume":"103","author":"Macher AM","year":"1988","journal-title":"Public Health Rep"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.6.3659-3667.2005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.12.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.2.956-963.2003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0902-0055.2001.00080.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/315872"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/339886"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1601-0825.2006.01226.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1601-0825.2006.01226.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:19:06Z","timestamp":1696976346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1601-0825.2006.01226.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,20]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1601-0825.2006.01226.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1601-0825.2006.01226.x","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,20]]}}}