{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:32:27Z","timestamp":1760887947132},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,10,20]],"date-time":"2006-10-20T00:00:00Z","timestamp":1161302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The purpose of this study was to evaluate the levels, molecular forms and activation degree of matrix metalloproteinase\u201013 (MMP\u201013) in the gingival crevicular fluid (GCF) of patients with periodontal diseases and to correlate these findings with periodontal clinical parameters.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sixty one subjects participated in this study as healthy (<jats:italic>n<\/jats:italic>\u2003=\u200318), gingivitis (<jats:italic>n<\/jats:italic>\u2003=\u200317), aggressive periodontitis (AgP; <jats:italic>n<\/jats:italic>\u2003=\u200315) and chronic periodontitis (CP; <jats:italic>n<\/jats:italic>\u2003=\u200311) groups. Clinical measurements and GCF samples were obtained from each subject. The molecular forms of MMP\u201013 in GCF samples were analyzed by Western immunoblotting method. Differences among the groups were assessed using non\u2010parametric statistical analysis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In the CP group, levels of 29\u201330\u2003kDa fragment of MMP\u201013, total MMP\u201013, and activated form of MMP\u201013 were significantly higher than in the healthy, gingivitis and AgP groups. GCF levels of all molecular forms of MMP\u201013 in AgP group were similar to those of healthy and gingivitis groups. Total and activated MMP\u201013 levels were positively correlated with all clinical parameters. 29\u201330\u2003kDa fragment levels of MMP\u201013 were also positively correlated with papillary bleeding index and plaque index.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These results indicate that elevated GCF MMP\u201013 levels may play an important role in the pathogenesis of CP. These data demonstrate, for the first time, pathologically activated and elevated MMP\u201013 in GCF.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2006.01244.x","type":"journal-article","created":{"date-parts":[[2006,10,20]],"date-time":"2006-10-20T10:53:31Z","timestamp":1161341611000},"page":"573-579","source":"Crossref","is-referenced-by-count":24,"title":["Gingival crevicular fluid matrix metalloproteinase\u201013 levels and molecular forms in various types of periodontal 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