{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:49:41Z","timestamp":1785548981602,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T00:00:00Z","timestamp":1152489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> To investigate the accuracy of histological diagnosis of oral hemangioma, oral vascular malformation and oral pyogenic granuloma according to immunohistochemical evaluation of the human erythrocyte\u2010type glucose transporter protein (GLUT\u20101), and to observe the immunoexpression of this protein in oral varix.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> Immunohistochemistry for GLUT\u20101 was performed in 93 histologically diagnosed cases of oral benign vascular lesions: 17 vascular malformations, 19 hemangiomas, nine varix, and 48 pyogenic granulomas. Descriptive analyses were performed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> None of the cases of the oral benign vascular lesions evaluated were immunopositive to GLUT\u20101. The 19 cases histologically diagnosed as oral hemangioma that showed negative staining to GLUT\u20101 were reclassified as oral pyogenic granuloma or oral vascular malformations. The histological evaluation itself is not enough to obtain the correct diagnosis of oral HEM as none of the sample cases were true hemangioma. All sample cases with initial vascular malformation or pyogenic granulomas classification were negative to GLUT\u20101, demonstrating the accuracy of histological diagnosis of these lesions itself. Oral varix showed negative staining to GLUT\u20101 in blood vessels.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> GLUT\u20101 is an useful, effective and important auxiliary marker for the diagnosis of oral benign vascular lesions.<\/jats:p><jats:p><jats:bold>Clinical relevance:\u2002<\/jats:bold> This study showed that histological diagnosis alone is not sufficient to correct diagnoses of oral hemangioma. Moreover, immunohistochemistry to GLUT\u20101 is a useful and easy diagnostic method that may be used to avoid such misdiagnosis. Accurate diagnosis of these oral lesions has an important clinical relevance allowing: (1) correct management, (2) adequate communication among the multidisciplinary team (dentist, dermatologist, pediatrist, radiologist, pathologist, and surgeon), (3) understanding of the biological behavior of the lesions, and (4) facilitate the development of new therapeutic modalities. Thus, supporting the use of this marker in medical and dentistry communities is warranted.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2006.01246.x","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T18:00:34Z","timestamp":1152554434000},"page":"51-55","source":"Crossref","is-referenced-by-count":28,"title":["GLUT\u20101 in oral benign vascular lesions"],"prefix":"10.1111","volume":"13","author":[{"given":"ACBR","family":"Johann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JT","family":"Salla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RS","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MCF","family":"De Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gontijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RA","family":"Mesquita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00729-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-2134-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.012682"},{"key":"e_1_2_6_5_1","first-page":"375","article-title":"Vascular tumors and vascular malformations (new issues)","volume":"13","author":"Enjolras O","year":"1997","journal-title":"Adv Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01843.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(83)80043-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.01.046"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2004.05.029"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00022744-199903000-00013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2003.09.017"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.10.670"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198203000-00002"},{"key":"e_1_2_6_14_1","first-page":"41","volume-title":"Vascular birthmarks: hemangiomas and vascular malformations","author":"Mulliken JB","year":"1988"},{"key":"e_1_2_6_15_1","first-page":"467","volume-title":"Oral & maxillofacial pathology","author":"Neville BW","year":"2002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.02.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80192-6"},{"key":"e_1_2_6_18_1","first-page":"559","article-title":"A unique microvascular phenotype shared by juvenile hemangiomas and human placenta","volume":"137","author":"North PE","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.12.1607"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90340-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(01)00150-0"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2002.7010"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970915)80:6<1046::AID-CNCR6>3.0.CO;2-7"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1601-0825.2006.01246.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1601-0825.2006.01246.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T05:37:53Z","timestamp":1697261873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1601-0825.2006.01246.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1601-0825.2006.01246.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1601-0825.2006.01246.x","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}