{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:26:55Z","timestamp":1779917215420,"version":"3.53.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T00:00:00Z","timestamp":1166745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold>To investigate the clinicopathological characteristics and biologic behaviour of epithelioid hemangioendothelioma in the oral cavity.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold>The clinical features and pathological findings of nine cases with intraoral epithelioid hemangioendothelioma were reviewed, including immunohistochemistry study.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>This series comprised seven males and two females aged 6\u201353\u2003years (mean 28\u2003years). The sites of the tumour included the tongue (<jats:italic>n<\/jats:italic>\u2003=\u20034), lip (<jats:italic>n<\/jats:italic>\u2003=\u20031), the gingiva and alveoli of the maxilla (<jats:italic>n<\/jats:italic>\u2003=\u20031), the gingiva and alveoli of the mandible (<jats:italic>n<\/jats:italic>\u2003=\u20031), buccal mucosa (<jats:italic>n<\/jats:italic>\u2003=\u20031), and the floor of the mouth (<jats:italic>n<\/jats:italic>\u2003=\u20031). A painless solitary mass was the most common presentation and was found in eight cases. On pathology, the tumour grew in short strands, cords or nests of polygonal to slightly spindled epithelioid cells in fibro\u2010myxoid stroma, with formation of intracytoplasmic lumina. Tumour cells were immunoreactive to CD34, FVIIIRAg, and vimentin. Focal\u2010positive cytokeration were observed in three cases. Immunoreactivity for S\u2010100 protein, epithelial membrane antigen (EMA) and human herpesvirus (HHV)\u20108 was negative in all cases. Two cases recurred after surgical excision, but no patient developed local or distant metastasis.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>Wide local excision with long\u2010term follow\u2010up seems to be the treatment of choice for intraoral epithelioid hemangioendothelioma because of their unpredictable biological behaviour and recurrence potential.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2006.01281.x","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T11:56:43Z","timestamp":1166788603000},"page":"244-250","source":"Crossref","is-referenced-by-count":25,"title":["Epithelioid hemangioendothelioma of the oral 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