{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:10:28Z","timestamp":1793434228483,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:00:00Z","timestamp":1172102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:\u2002<\/jats:bold>\n                    Patients with oral submucous fibrosis (OSF) suffer from the limitation of the oral opening. The aim of this study was to develop a simple and rapid method to improve the opening of the oral cavity and determine its effect on the incidence of developing oral carcinoma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    We first induced an OSF\u2010like lesion in rabbits which histopathologically resembles OSF in betel nut chewers and evaluated the effects of exogenous collagenase on these lesions. We then applied the collagenase treatment regimen to patients with OSF.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Endogenous collagenase activities in normal oral mucosa of patients exhibited 3\u2010 to 5\u2010fold higher levels than that of OSF tissues. The collagenase treatment not only resulted in a significant improvement of oral opening, but patients also experienced a striking reduction in hypersensitivity to spices, sour, cold, and heat which helped restore eating function. Sub\u2010mucosal fibrous proliferation, persistently good vascularization, and a mild increase in thickness of the sub\u2010mucosal fibrous tissues were noticed 10\u2003months after collagenase treatment. Within the 2\u2010year follow\u2010up period none of the treated patients developed an oral squamous cell carcinoma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    A reduced content of functional collagenase observed in OSF mucosa of patients might be one mechanism responsible for collagen accumulation. Intervention of OSF by collagenase treatment at the early stage may reduce the incidence of developing oral carcinoma.\n                  <\/jats:p>","DOI":"10.1111\/j.1601-0825.2006.01313.x","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T12:14:13Z","timestamp":1172146453000},"page":"407-413","source":"Crossref","is-referenced-by-count":55,"title":["Treatment of oral submucous fibrosis by collagenase: effects on oral opening and eating function"],"prefix":"10.1111","volume":"13","author":[{"given":"H\u2010J","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010C","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.01.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1096\/fasebj.5.8.1850705","article-title":"Molecular cloning and expression of collagenase\u20103, a novel human matrix metalloproteinases and their inhibitors in connective tissue remodeling","volume":"5","author":"Freije MP","year":"1991","journal-title":"FASEB J"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"10\u2003048","DOI":"10.1016\/S0021-9258(18)61073-7","article-title":"The collagen substrate specificity of human neutrophil collagenase","volume":"262","author":"Hasty KA","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_6_5_1","volume-title":"Betel\u2010quid and areca\u2010nut chewing and some areca nut derived nitrosoamines","author":"IARC","year":"2004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00003-3"},{"key":"e_1_2_6_7_1","first-page":"92","article-title":"Role of placental extract in management of oral submucous fibrosis. 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