{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:12:13Z","timestamp":1762323133033},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T00:00:00Z","timestamp":1178150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>Paracoccidioidomycosis (Pmycosis) is one of the most common deep mycoses in many regions of Latin America, particularly in Brazil. Microscopically, it shows granulomatous inflammatory reaction with giant cells, macrophages, lymphocytes, plasma cells, polymorphonuclear neutrophilic leukocytes, and eosinophils. The purpose of this study was to assess the distribution of inflammatory cells in oral Pmycosis. Fifteen cases of oral Pmycosis were studied by immunohistochemistry for the presence of macrophages, CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> lymphocytes, CD20<jats:sup>+<\/jats:sup>, CD15<jats:sup>+<\/jats:sup>, and S100<jats:sup>+<\/jats:sup> cells. Macrophages were the main cells in well\u2010organized granulomas and non\u2010granulomatous areas. The CD4 phenotype was predominant in well\u2010organized granulomas and a balance between CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> cells was observed in non\u2010granulomatous areas. Dendritic, S100<jats:sup>+<\/jats:sup> cells were found mainly in the epithelium, in subepithelial connective tissue, and at the periphery of organized granulomas. CD15<jats:sup>+<\/jats:sup> cells were concentrated mainly in areas of intraepithelial microabscess and ulceration. Macrophages and T cells are the predominant cells in oral Pmycosis. Well\u2010organized granulomas contain fewer yeast particles, indicating a more effective host immune response. Better understanding of the histopathological changes in oral Pmycosis might help determine treatment, severity and systemic involvement of the disease.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2006.01319.x","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T04:35:08Z","timestamp":1178685308000},"page":"434-439","source":"Crossref","is-referenced-by-count":17,"title":["Characterization of inflammatory cells in oral paracoccidioidomycosis"],"prefix":"10.1111","volume":"13","author":[{"given":"E","family":"Kaminagakura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PRF","family":"Bonan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OP","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Scully","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90554-P"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400508"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4269\/ajtmh.1999.61.280","article-title":"Macrophage expression of class II major histocompatibility complex gene products in Paracoccidioides brasiliensis\u2010infected mice","volume":"61","author":"Bocca AL","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651994000200016"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681219780001161"},{"key":"e_1_2_6_7_1","first-page":"151","volume-title":"Paracoccidioidomycosis","author":"Calich VLG","year":"1993"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821987000200012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.123.4.479"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.28.2.557-566.1980"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00436927"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(99)00039-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/714030926"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681218780000231"},{"key":"e_1_2_6_15_1","first-page":"430","article-title":"In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoescleroma and sarcoidosis","volume":"51","author":"Moldin RL","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681218980000211"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.40.4.407.410"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200304000-00003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681219180000601"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.39.3.233.241"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689699500300306"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb01013.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90171-Y"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681218880000521"},{"key":"e_1_2_6_25_1","unstructured":"VillalbaH(1998).Caracter\u00edsticas microsc\u00f3picas da paracoccidioidomicose bucal. 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