{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:18:05Z","timestamp":1781871485379,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T00:00:00Z","timestamp":1175040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> The expression of tenascin\u2010C in the synovial membrane of the internal derangement (ID) of the temporomandibular joint (TMJ) has been reported. Hypoxia of the synovial membrane in TMJ is considered to be a cause for the pathophysiology of ID. In this study, we clarify the contribution of hypoxia and interleukin\u20101<jats:italic>\u03b2<\/jats:italic> in the expression of tenascin\u2010C in ID of TMJ.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> Synovial fibroblasts and disk cells obtained from ID of TMJs were cultured and treated with interleukin\u20101<jats:italic>\u03b2<\/jats:italic> under normoxia and hypoxia. A Western blot analysis and reverse transcription\u2010polymerase chain reaction analysis were used to identify tenascin\u2010C in cultured synovial fibroblasts and disk cells. In addition, the immunohistochemical staining of tenascin\u2010C was carried out for the specimens of ID of TMJs and normal.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The combination of hypoxia and interleukin\u20101<jats:italic>\u03b2<\/jats:italic> caused a significant increase in tenascin\u2010C protein and mRNA of synovial fibroblasts. In contrast, the combination caused no increase in tenascin\u2010C in disk cells. However, the immunohistochemical staining demonstrated tenascin\u2010C to be significantly detected in both the synovial tissue and disks in ID of TMJ.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results indicate that hypoxic conditions with inflammation modulate the tenascin\u2010C expression in synovial fibroblasts, but not in disk cells.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2006.01344.x","type":"journal-article","created":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T13:50:33Z","timestamp":1175089833000},"page":"45-50","source":"Crossref","is-referenced-by-count":22,"title":["Effect of hypoxia and interleukin\u20101<i>\u03b2<\/i> on expression of tenascin\u2010C in temporomandibular 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