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These are characterized by a spectrum of chromosomal, genetic, and molecular alterations that they share with each other as well as with the malignant lesions that develop from them. In this review we summarize the investigation of the molecular genetics of each of these lesions and relate them to the alterations, which have been demonstrated in OSCC, to define their location on the continuum of changes, which lead to malignant transformation.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2006.01349.x","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T02:38:50Z","timestamp":1171420730000},"page":"126-133","source":"Crossref","is-referenced-by-count":153,"title":["Molecular genetics of premalignant oral lesions"],"prefix":"10.1111","volume":"13","author":[{"given":"SK","family":"Mithani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WK","family":"Mydlarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FL","family":"Grumbine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IM","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JA","family":"Califano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"214","article-title":"p53 aberrations in oral sub mucous fibrosis and oral cancer detected by immunohistochemistry","volume":"14","author":"Bathi RJ","year":"2003","journal-title":"Indian J Dent Res"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(88)90166-1"},{"key":"e_1_2_7_4_1","first-page":"294","article-title":"Oral lichen planus. 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