{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:58:49Z","timestamp":1758707929790},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T00:00:00Z","timestamp":1193788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To explore the type and prevalence of oral mucosal lesions among adults with primary HIV infection (PHI) compared with HIV\u2010negative adults at high risk for HIV disease, and in relation to HIV viral load.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We conducted standardized oral examinations to identify specific oral mucosal lesions among adults with PHI, both <jats:italic>pre\u2010seroconversion<\/jats:italic> and <jats:italic>post\u2010 seroconversion<\/jats:italic>\u2010recently infected, compared with HIV\u2010negative adults. We compared the group with oral lesions to those without oral lesions with respect to HIV\u2010RNA load and CD4\u2003+\u2003T\u2010cell count.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Among 115 adults (predominantly men), pseudomembranous candidiasis was the most common oral lesion among those with PHI, and was found in 4% of the 23 participants in <jats:italic>pre\u2010seroconversion<\/jats:italic> and in 9% of 69 participants with <jats:italic>post\u2010seroconversion<\/jats:italic> recent infection, compared with none found among 23 HIV negatives. Among those with PHI, the median viral load was higher and the median CD4\u2003+\u2003T\u2010cell count lower among the 15 participants with an oral lesion of any type than among the 77 participants without oral lesions (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.02 and 0.04, respectively).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This finding suggests that individuals with PHI who have oral lesions may be more likely to transmit HIV because of their higher viral load.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2007.01407.x","type":"journal-article","created":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T10:18:48Z","timestamp":1193825928000},"page":"497-499","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence of oral disease among adults with primary HIV infection*"],"prefix":"10.1111","volume":"14","author":[{"given":"FJ","family":"Owotade","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CH","family":"Shiboski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Poole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CA","family":"Ramstead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Malvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FM","family":"Hecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JS","family":"Greenspan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462021924613"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.00013.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1993.tb01074.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199105000-00007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90195-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/382750"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90185-S"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200009010-00006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200205240-00005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/506616"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.108799"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199910220-00026"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-4-199608150-00001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.10.925"},{"key":"e_1_2_6_16_1","first-page":"964","article-title":"HIV\u2010related oral manifestations in two cohorts of women in San Francisco","volume":"7","author":"Shiboski CH","year":"1994","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.156.19.2249"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-139X(01)00280-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000218357.82970.67"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1601-0825.2007.01407.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1601-0825.2007.01407.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:48:08Z","timestamp":1696985288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1601-0825.2007.01407.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,13]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1111\/j.1601-0825.2007.01407.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1601-0825.2007.01407.x","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,13]]}}}