{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:13:56Z","timestamp":1791252836552,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,2,10]],"date-time":"2008-02-10T00:00:00Z","timestamp":1202601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> The oral cavity is constantly lubricated by saliva and even small amounts of xenobiotics and\u200a\/\u200aor their metabolites in the saliva may affect the oral mucosa. Our aim was therefore to clarify if xenobiotic metabolizing enzymes CYP1A2 and CYP3A4 are expressed in salivary glands.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Formalin\u2010fixed paraffin\u2010embedded specimens from parotid (10), submandibular (7) and labial (10) salivary glands were examined immunohistochemically and by <jats:bold><jats:italic>in situ<\/jats:italic><\/jats:bold> hybridization for expression of CYP1A2 and CYP3A4 protein and mRNA.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> CYP1A2 and CYP3A4 protein and mRNA were detected in ductal and seromucous\u200a\/\u200aserous acinar cells in all gland types although to a varying degree and intensity. Mucous acinar cells were positive to a lesser extent.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results indicate a xenobiotic metabolizing capability of salivary glands. This may have implications for development of oral mucosal disease as a result of mucosal exposure to metabolites originating from internal sources (blood) as well as from saliva.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2007.01415.x","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T07:30:01Z","timestamp":1202715001000},"page":"533-540","source":"Crossref","is-referenced-by-count":24,"title":["Expression of two drug\u2010metabolizing cytochrome P450\u2010enzymes in human salivary 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