{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:05:07Z","timestamp":1783188307332,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T00:00:00Z","timestamp":1216857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Lipid peroxidation (LPO) has been implicated in the pathogenesis of several pathologic disorders, including periodontal disease. Malondialdehyde (MDA) is one of many low molecular weight end products of LPO.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> This study was conducted to evaluate salivary MDA levels in generalized chronic periodontitis (GCP) subjects.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> The MDA levels were measured in the saliva of 104 subjects, aged 18\u201365\u2003years. Three groups with different degrees of severity of GCP were established: 30 early (group 1), 30 moderate (group 2) and 14 severe (group 3). Thirty individuals (aged 25\u201329\u2003years) with clinically healthy periodontium were served as control. Unstimulated whole saliva samples from study subjects were collected, centrifuged at 3000\u2003<jats:bold><jats:italic>g<\/jats:italic><\/jats:bold> for 15\u2003min and were then stored at \u221270\u00b0C until analysed. The MDA level was determined with 2\u2010thiobarbituric acid by a colorimetric method at 532\u2003nm.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A significant increase in the MDA level existed in the samples obtained from the three groups of patients compared to the control subjects.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Increased MDA levels are with closely associated with the severity and patients status of periodontal disease that has not been previously reported. The detection of salivary MDA level may provide additional advantages in elucidating the pathogenesis of periodontal disease.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2008.01464.x","type":"journal-article","created":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T01:32:13Z","timestamp":1216949533000},"page":"754-760","source":"Crossref","is-referenced-by-count":49,"title":["Salivary malondialdehyde levels in clinically healthy and periodontal diseased individuals"],"prefix":"10.1111","volume":"14","author":[{"given":"J","family":"Khalili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HF","family":"Biloklytska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01091.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.13"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb02088.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00159.x"},{"key":"e_1_2_7_6_1","first-page":"100","article-title":"Salivary lipid peroxidation product malonaldehde in various dental diseases","volume":"1","author":"Balwant R","year":"2006","journal-title":"World J Med Sci"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00003-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411990100040301"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290301x.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1071576031000083116"},{"key":"e_1_2_7_11_1","first-page":"29","article-title":"Indices characterizing the expression of hyperesthesia of the hard dental tissues in patients with periodontitis","volume":"1","author":"Beloklitskaia GF","year":"1992","journal-title":"Stomatologiia (Mosk)"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00760.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329703400413"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000395548"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4807861"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.12.1819"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/57.5.715S"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(99)00010-X"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1993.tb00570.x"},{"key":"e_1_2_7_20_1","first-page":"46","article-title":"Alteration of cyclic nucleotides levels and oxidative stress in saliva of human subjects with periodontitis","volume":"15","author":"Mashayekhi F","year":"2005","journal-title":"J\u00a0Contemp Dent Pract"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0181"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4801135"},{"key":"e_1_2_7_23_1","first-page":"107","article-title":"Gingival sulcus bleeding\u2013a leading symptom in initial gingivitis","volume":"15","author":"M\u00fchlemann HR","year":"1971","journal-title":"Helv Odontol Acta"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18343.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345820610100901"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.01.022"},{"key":"e_1_2_7_27_1","first-page":"255","article-title":"Lipid peroxidation and antioxidant status in patients with periodontitis","volume":"10","author":"Panjamurthy K","year":"2005","journal-title":"Cell Mol Biol Lett"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4680(02)00034-2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411950060020501"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00100.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2001.70109.x"},{"key":"e_1_2_7_32_1","first-page":"875","article-title":"Morphological examinations of hard tissue of periodontium and evaluation of selected processes of lipid peroxidation in blood serum of rats in the course of experimental periodontitis","volume":"6","author":"Sobaniec H","year":"2000","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_33_1","first-page":"838","article-title":"Correlation between morphological changes in gingival tissues and increased concentration of lipid peroxides in the course of experimental periodontitis in rats","volume":"5","author":"Sobaniec H","year":"1999","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01646.x"},{"key":"e_1_2_7_35_1","first-page":"66","volume-title":"Modern methods in biochemistry","author":"Stalnaya ID","year":"1977"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.1o834.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2005.03.009"},{"key":"e_1_2_7_38_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1128\/iai.51.1.49-53.1986","article-title":"Antimicrobial factors in whole saliva of human infants","volume":"51","author":"Tenovuo J","year":"1986","journal-title":"Infect Immun"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00818.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200202"},{"key":"e_1_2_7_41_1","first-page":"5","article-title":"The role of lipid peroxidation in the pathogenesis of periodontitis","volume":"4","author":"Voskresenski\u012d ON","year":"1991","journal-title":"Stomatologiia (Mosk)"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2000.tb00325.x"},{"key":"e_1_2_7_43_1","first-page":"594","article-title":"The periodontal disease classification system of the American Academy of Periodontology\u2013an update","volume":"66","author":"Wiebe CB","year":"2000","journal-title":"J\u00a0Can Dent Assoc"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00025-4"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00196-8"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1601-0825.2008.01464.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1601-0825.2008.01464.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T22:21:05Z","timestamp":1695939665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1601-0825.2008.01464.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,15]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1111\/j.1601-0825.2008.01464.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1601-0825.2008.01464.x","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,15]]}}}