{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:00:14Z","timestamp":1784757614631,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,13]],"date-time":"2010-12-13T00:00:00Z","timestamp":1292198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p> <jats:italic>Oral Diseases<\/jats:italic> (2010) <jats:bold>17<\/jats:bold>, 68\u201376<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To investigate possible relationship between smoking and serum concentrations of matrix metalloproteinase\u20108,\u20109 (MMP\u20108, MMP\u20109), tissue inhibitor of matrix metalloproteinases\u20101 (TIMP\u20101), neutrophil elastase (NE), myeloperoxidase (MPO) in chronic periodontitis (CP) patients relative to periodontally healthy subjects.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Serum samples were obtained from 111 subjects before initiation of any periodontal intervention. Fifty\u2010five CP patients (39 non\u2010smokers, 16 smokers) and 56 periodontally healthy subjects (39 non\u2010smokers, 17 smokers) were recruited. Serum concentrations of MMP\u20108 were determined by IFMA and MPO, MMP\u20109, TIMP\u20101, NE concentrations by ELISA. ANCOVA and Pearson correlation analysis was utilized for statistical analysis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Serum MPO, NE concentrations were higher in smoker CP than non\u2010smoker CP patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.002 and <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001, respectively), whereas these were similar in smoker, non\u2010smoker periodontally healthy groups (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05). TIMP\u20101 concentration was higher in non\u2010smoker CP than smoker CP group (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). MMP\u20109\/TIMP\u20101 ratios were higher in smoker CP than non\u2010smoker CP group (<jats:italic>P<\/jats:italic>\u2003=\u20030.01). MMP\u20108 concentrations, MMP\u20108\/TIMP\u20101 and MMP\u20109\/TIMP\u20101 ratios in CP group were not significantly different from those in periodontally healthy group (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our findings of significantly elevated serum MMP\u20109, MPO, NE together with decreased TIMP\u20101 in smoker CP patients than non\u2010smokers support that smoking together with periodontal destruction may expose\/predispose to cardiovascular diseases.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2010.01705.x","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T10:09:57Z","timestamp":1279620597000},"page":"68-76","source":"Crossref","is-referenced-by-count":65,"title":["Smoking and matrix metalloproteinases, neutrophil elastase and myeloperoxidase in chronic periodontitis"],"prefix":"10.1111","volume":"17","author":[{"given":"\u00d6","family":"\u00d6z\u00e7aka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"B\u0131\u00e7akc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Pussinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"K\u00f6se","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Buduneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00285.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1996.tb00142.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.09.023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345990780120301"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01382.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027001061.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.6.9809043"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090130"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260604.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290613.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.1.103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00892.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.050451"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290815.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.18.11023"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.9.5871"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070623"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.1.23"},{"key":"e_1_2_7_21_1","first-page":"1504","article-title":"Matrix metalloproteinase\u20108 is expressed in rheumatoid synovial fibroblasts and endothelial cells. 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