{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:27:15Z","timestamp":1762079235380},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T00:00:00Z","timestamp":1285200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>Oral Diseases (2011) <jats:bold>17<\/jats:bold>, 258\u2013264<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To analyse and compare the expression of Palate, Lung, and Nasal Epithelium Clone (PLUNC) proteins in salivary glands from patients with and without AIDS (control group) using autopsy material.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We analysed the expression of PLUNCs using immunohistochemistry in parotid (<jats:italic>n<\/jats:italic>\u2003=\u200345), submandibular (<jats:italic>n<\/jats:italic>\u2003=\u200347) and sublingual gland (<jats:italic>n<\/jats:italic>\u2003=\u200337) samples of AIDS patients [30 with normal histology, 21 with mycobacteriosis, 14 with cytomegalovirus (CMV) infection, 30 with chronic non\u2010specific sialadenitis, and 30 HIV\u2010negative controls. <jats:italic>In situ<\/jats:italic> hybridization (ISH) for SPLUNC 2 in the HIV\u2010negative group was performed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> SPLUNC 1 expression was detected in the mucous acini of submandibular and sublingual glands, and SPLUNC 2 were seen in the serous cells. LPLUNC 1 expression was only positive in the salivary ducts. There was a higher expression of SPLUNC 2 in AIDS patients with CMV infection and mycobacteriosis when compared with all other groups. The intensity of staining for SPLUNC 2 was greater around the lesions than the peripheral ones. ISH for SPLUNC 2 showed perinuclear positivity in the serous cells in all HIV\u2010negative cases.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> SPLUNC 1 and LPLUNC 1 proteins were similarly expressed in the salivary glands of AIDS patients and non\u2010HIV patients.\u2003CMV infection and mycobacteriosis increase SPLUNC 2 expression in serous cells\u2003in the salivary gland of AIDS patients.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2010.01733.x","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T11:22:14Z","timestamp":1285240934000},"page":"258-264","source":"Crossref","is-referenced-by-count":6,"title":["PLUNC protein expression in major salivary glands of HIV\u2010infected patients"],"prefix":"10.1111","volume":"17","author":[{"given":"AA","family":"da 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