{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:30:08Z","timestamp":1777120208173,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T00:00:00Z","timestamp":1285200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p> <jats:italic>Oral Diseases<\/jats:italic> (2011) <jats:bold>17<\/jats:bold>, 270\u2013276<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Coronary heart disease (CHD) and chronic periodontitis (CP) both are multifactorial chronic diseases and related to inflammation. Interleukin\u20106 (IL\u20106) plays an important role in the pathogenesis of inflammatory diseases. The purpose of the study was to investigate the association among IL\u20106 gene polymorphisms, CP and CHD susceptibility in a Chinese population.<\/jats:p><jats:p><jats:bold>Material and methods:\u2002<\/jats:bold> The investigation was conducted as a case\u2010control study involving 505 individuals: 113 patients with CHD and CP, 84 patients with CHD, 178 patients with CP and 130 control individuals. The polymorphisms of IL\u20106 gene were analyzed by polymerase chain reaction\u2010restriction fragment length polymorphism. Relationships between the distributions of the genotypes and risk factors were also assessed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Mutations at the loci \u2010174\u2003G\/C, \u2010597\u2003G\/A of IL\u20106 were rare in a Chinese population. No significant difference for IL\u20106\u2010572C\/G polymorphism was detected among moderate CP group, severe CP group and control (<jats:italic>P<\/jats:italic>\u2003=\u20030.312 and 0.481), significant differences were found between CHD groups and non\u2010CHD groups (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030.001). After adjustment for CHD risk factors, the G allele resulted in an increased risk (OR\u2003=\u20031.676\u20101.856), the GG\/CG genotype was nearly two times higher risk compared to CC genotype (OR\u2003=\u20032.010\u20102.136).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> IL\u20106\u2010572C\/G polymorphism did not correlate with CP susceptibility, but might be a potential risk factor for CHD in a Chinese population.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2010.01736.x","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T11:22:34Z","timestamp":1285240954000},"page":"270-276","source":"Crossref","is-referenced-by-count":36,"title":["Coronary heart disease and chronic periodontitis: is polymorphism of interleukin\u20106 gene the common risk factor in a Chinese 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