{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:38:24Z","timestamp":1769121504572,"version":"3.49.0"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T00:00:00Z","timestamp":1301356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2011) <jats:bold>17<\/jats:bold>, 621\u2013627<\/jats:p><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) is a widely prevalent microbe, with between 50 and 80% of the population infected worldwide. Clinically, infection with <jats:italic>H. pylori<\/jats:italic> is commonly associated with peptic ulcer disease, but many of those infected remain asymptomatic. <jats:italic>H. pylori<\/jats:italic> has evolved a number of means to affect the host immune response and has been implicated in many diseases mitigated by immune dysregulation, such as immune thrombocytopenic purpura (ITP), atrophic gastritis, and mucosa associated lymphoid tissue (MALT) lymphoma. Autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Sjogren\u2019s syndrome, are the result of a dysregulated host immune system which targets otherwise healthy tissues. The exact etiology of autoimmune diseases is unclear, but it has long been suggested that exposure to certain environmental agents, such as viral and bacterial infection or chemical exposures, in genetically susceptible individuals may be the catalyst for the initiation of autoimmune processes. Because of its prevalence and ability to affect human immune function, many researchers have hypothesized that <jats:italic>H. pylori<\/jats:italic> might contribute to the development of autoimmune diseases. In this article, we review the available literature regarding the role of chronic <jats:italic>H. pylori<\/jats:italic> infection in various autoimmune disease states.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01796.x","type":"journal-article","created":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T13:29:39Z","timestamp":1295357379000},"page":"621-627","source":"Crossref","is-referenced-by-count":54,"title":["<i>Helicobacter pylori<\/i> and autoimmune diseases"],"prefix":"10.1111","volume":"17","author":[{"given":"S","family":"Hasni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ippolito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GG","family":"Illei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030530"},{"key":"e_1_2_12_3_1","first-page":"1306","article-title":"Presence of antibodies against Helicobacter pylori and its heat\u2010shock protein 60 in the serum of patients with Sjogren\u2019s syndrome","volume":"26","author":"Aragona P","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.593"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00703.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.09.024"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"S3","article-title":"Key points from the revised Maastricht Consensus Report: the impact on general practice","volume":"13","author":"Bazzoli F","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119588"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a018040"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00631.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2008.00543.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01393.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010501"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400307"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2004.04.005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.3.812"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70130-8"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.1918"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04132.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008924"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3925"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/315257"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.2.134"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00684.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.1.72"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20258"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00711.x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.11.747"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00603.x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1556\/AMicr.51.2004.3.9"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91473-Y"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.06188"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2007.11.004"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08025-X"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101634"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.06.021"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60013-5_9"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8158-6"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1497"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.23.2240"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2009"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.12.008"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8048-8"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0480180"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2007.01.001"},{"key":"e_1_2_12_49_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1182\/blood.V90.2.766","article-title":"Lymphomas in patients with Sjogren\u2019s syndrome are marginal zone B\u2010cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses","volume":"90","author":"Royer B","year":"1997","journal-title":"Blood"},{"key":"e_1_2_12_50_1","first-page":"1546","article-title":"Association between systemic lupus erythematosus and Helicobacter pylori seronegativity","volume":"31","author":"Sawalha AH","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_12_52_1","first-page":"1195","article-title":"Helicobacter pylori infection in rheumatoid arthritis","volume":"28","author":"Seriolo B","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1996.tb01100.x"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.3.218"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.09.014"},{"key":"e_1_2_12_56_1","article-title":"The effect of Helicobacter pylori eradication on C\u2010reactive protein and the lipid profile in patients with rheumatoid arthritis using chronic NSAIDs","volume":"27","author":"Steen KS","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.3.1263"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.2.224"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401528101"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41641.x"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-005-0419-5"},{"key":"e_1_2_12_63_1","first-page":"633","article-title":"Seroprevalence of Helicobacter pylori in primary Sjogren\u2019s syndrome","volume":"19","author":"Theander E","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1999.tb00012.x"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655201317097155"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700808"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"e_1_2_12_68_1","first-page":"1780","article-title":"Natural acquisition and spontaneous elimination of Helicobacter pylori infection: clinical implications","volume":"92","author":"Xia HH","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.248-256.2006"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01284.x"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1601-0825.2011.01796.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1601-0825.2011.01796.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:38:18Z","timestamp":1697308698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1601-0825.2011.01796.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,29]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1601-0825.2011.01796.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1601-0825.2011.01796.x","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,29]]}}}