{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:55:27Z","timestamp":1794563727727,"version":"4.9.1"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T00:00:00Z","timestamp":1297987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>\n                    <jats:italic>Oral Diseases<\/jats:italic>\n                    (2011)\n                    <jats:bold>17<\/jats:bold>\n                    , 522\u2013529\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:\u2002<\/jats:bold>\n                    The aim of this study was to compare the levels of interleukin\u201012 (IL\u201012) and IL\u201018 in gingival tissue and serum between patients with chronic (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200318) or aggressive periodontitis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200312) and healthy subjects (HS) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u20039).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Gingival tissue biopsies and serum were obtained from all study subjects. The tissue was homogenized and cytokines IL\u201012 and IL\u201018 were quantified by enzyme\u2010linked immunosorbent assay.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Interleukin\u201012 levels in gingival tissue were significantly higher in aggressive periodontitis patients than in HS; serum IL\u201012 was significantly elevated in aggressive periodontitis relative to both chronic periodontitis (CP) and HS. IL\u201018 levels in gingival tissue showed no significant differences between the groups. Patients with CP showed significantly elevated levels of serum IL\u201018 compared with HS; however, the aggressive periodontitis group showed no significant differences with either the CP group or the HS.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Our results showed higher levels of IL\u201012 in gingival tissue and serum of patients with aggressive periodontitis, and IL\u201018 was elevated in the serum of CP patients. The patterns of IL\u201012 and IL\u201018 are different in chronic and aggressive periodontitis; this finding suggests distinctive mechanisms of immunopathogenesis between these forms of periodontitis.\n                  <\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01798.x","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T02:17:27Z","timestamp":1297995447000},"page":"522-529","source":"Crossref","is-referenced-by-count":45,"title":["IL\u201012 and IL\u201018 levels in serum and gingival tissue in aggressive and chronic periodontitis"],"prefix":"10.1111","volume":"17","author":[{"given":"PE","family":"S\u00e1nchez\u2010Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AL","family":"Zamora\u2010Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fuentes\u2010Lerma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Robles\u2010G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RP","family":"Mariaud\u2010Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Guerrero\u2010Vel\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5368.1432"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0356"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208101012"},{"key":"e_1_2_7_7_1","first-page":"147","article-title":"Markers of systemic inflammation in periodontal patients: chronic versus aggressive periodontitis. 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