{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:48:02Z","timestamp":1770914882763,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T00:00:00Z","timestamp":1312761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2011) <jats:bold>17<\/jats:bold>, 808\u2013812<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01841.x","type":"journal-article","created":{"date-parts":[[2011,7,24]],"date-time":"2011-07-24T16:18:20Z","timestamp":1311524300000},"page":"808-812","source":"Crossref","is-referenced-by-count":27,"title":["Expression of fatty acid synthase (FASN) in oral nevi and melanoma"],"prefix":"10.1111","volume":"17","author":[{"given":"BAB","family":"de 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