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IL\u20106 is emerging as an important mediator and novel therapeutic target for chronic inflammatory diseases and cancer. The present study reviews the available evidence regarding the association between IL\u20106 and a range of oral diseases including infections (periodontal disease and endodontic infections), immunologically mediated disorders (oral lichen planus and Sj\u00f6gren\u2019s syndrome) and malignancy (oral cancer and precancer). The role of common genetic variants of IL\u20106 in determining individual susceptibility to certain oral diseases, as well as novel therapeutic strategies based on IL\u20106 inhibition are also discussed.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01867.x","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T20:44:11Z","timestamp":1318365851000},"page":"236-243","source":"Crossref","is-referenced-by-count":133,"title":["Interleukin\u20106 in oral diseases: a review"],"prefix":"10.1111","volume":"18","author":[{"given":"L","family":"Nibali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"D\u2019Aiuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Donos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204685"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.744-750.2001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1999.tb00744.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.9.4.737"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363882"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090590"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.11.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.037531"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.01.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0746"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2003.22108.x"},{"key":"e_1_2_9_13_1","first-page":"1369","article-title":"Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer","volume":"5","author":"Chen Z","year":"1999","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090510"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300214"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.06.005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400312"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00067-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01272.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.091256"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.05.004"},{"key":"e_1_2_9_22_1","unstructured":"FerlayJ ShinHR BrayF FormanD MathersC ParkinDM(2008).GLOBOCAN 2008 cancer incidence and mortality worldwide: IARC CancerBase No. 10 [Internet].International Agency for Research on Cancer Lyon France. 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