{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T16:27:19Z","timestamp":1788107239839,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,14]],"date-time":"2011-11-14T00:00:00Z","timestamp":1321228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>18<\/jats:bold>, 265\u2013270<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Increasing evidence indicates that microRNAs (miRNAs) play a vital role in the pathogenesis of inflammatory and autoimmune diseases. The objective of this study was to investigate the altered miRNA expression profile in patients with oral lichen planus (OLP) and determine the miR\u201027b expression.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We compared miRNA expression patterns in oral biopsy specimens from patients with OLP (<jats:italic>n<\/jats:italic>\u2003=\u20033) with those from normal controls (<jats:italic>n<\/jats:italic>\u2003=\u20033) using microarray technology. We further assessed the miR\u201027b expression in specimens from patients with OLP (<jats:italic>n<\/jats:italic>\u2003=\u200353) against controls (<jats:italic>n<\/jats:italic>\u2003=\u200334) using real\u2010time quantitative PCR (RT\u2010QPCR), and miR\u201027b expression in specimens from patients with OLP (<jats:italic>n<\/jats:italic>\u2003=\u200315) against controls (<jats:italic>n<\/jats:italic>\u2003=\u200312) using in situ hybridization (ISH).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Using microarray analysis, a total of 46 differentially expressed miRNAs with more than 2\u2010fold change were identified, including 8 up\u2010regulated and 38 down\u2010regulated miRNAs. Both RT\u2010QPCR and ISH analyses revealed that miR\u201027b was significantly down\u2010regulated in OLP tissue, and miR\u201027b expression was even more suppressed in atrophic\u2010erosive OLP than in reticular OLP. In addition, miR\u201027b was found to be expressed in the epithelial keratinocyte layer of both normal and OLP tissues.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These data indicate that miRNAs may be the novel candidate biomarkers for the implication of miRNAs in the pathogenesis of OLP.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01869.x","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T14:21:48Z","timestamp":1318947708000},"page":"265-270","source":"Crossref","is-referenced-by-count":34,"title":["Altered microRNA expression profile with miR\u201027b down\u2010regulation correlated with disease activity of oral lichen planus"],"prefix":"10.1111","volume":"18","author":[{"given":"W\u2010Y","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010M","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X\u2010M","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010F","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u2010Y","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27329"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00894.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1819210"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01516.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2011.01.007"},{"key":"e_1_2_7_8_1","article-title":"Altered 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