{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:53:49Z","timestamp":1793307229122,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,14]],"date-time":"2011-11-14T00:00:00Z","timestamp":1321228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>18<\/jats:bold>, 271\u2013279<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Interleukin\u201010 gene promoter polymorphisms have been associated with interleukin\u201010 decreased production, thereby playing a role in the pathogenesis of periodontitis. This study aimed to investigate whether interleukin\u201010 single nucleotide polymorphisms at positions \u20101087(G\/A) and \u2010597(C\/A) are associated with generalised chronic periodontitis and localised aggressive periodontitis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Genomic DNA samples were isolated from 276 unrelated Jordanian participants. Subjects were categorised into 86 periodontally healthy controls, 105 chronic periodontitis patients and 85 localised aggressive periodontitis patients. Genotype frequencies were calculated, and differences were determined using Pearson chi\u2010squared test, and odds ratio and 95<jats:bold>%<\/jats:bold> confidence intervals were included.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The frequencies of the \u20101087A and \u2010597A alleles were significantly more common in chronic periodontitis patients than controls. The A\u2010positive allele genotypes (GA, AA) at position \u20101087 and A\u2010positive allele genotypes (CA, AA) at position \u2010597 appeared to increase the risk of having chronic periodontitis. No significant differences were observed in the genotype frequencies between localised aggressive periodontitis patients and controls.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These findings indicate the possible use of interleukin\u201010 single nucleotide polymorphisms as genetic markers in chronic periodontitis patients and further emphasise the molecular differences between chronic periodontitis and aggressive periodontitis.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01872.x","type":"journal-article","created":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T19:31:04Z","timestamp":1319225464000},"page":"271-279","source":"Crossref","is-referenced-by-count":31,"title":["Association of interleukin\u201010 gene promoter polymorphisms with chronic and aggressive 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