{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:50:36Z","timestamp":1759963836781},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T00:00:00Z","timestamp":1324944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>18<\/jats:bold>, 360\u2013364<\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Alteration of salivary gland secretion is one of the consequences of diabetes. In a recent study on the submandibular gland of diabetic subjects, we found changed expression of statherin, a salivary protein of fundamental importance in preserving tooth integrity, whose reduction was related with the high incidence of oral diseases in patients with diabetes. The goal of this report is to extend the study to human parotid gland and to compare the effects of diabetes on statherin expression with those previously described in submandibular gland.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u00a0<\/jats:bold> Fragments of parotid glands obtained from diabetic and non\u2010diabetic patients were fixed, dehydrated, embedded in Epon Resin and processed for the immunogold histochemistry. The staining density was expressed as number of gold particles per \u03bcm<jats:sup>2<\/jats:sup> and statistically evaluated.<\/jats:p><jats:p><jats:bold>Results and Conclusions:\u00a0<\/jats:bold> In all samples, statherin reactivity was specifically localized in secretory granules of acinar cells. The statistical analysis showed that labelling density was significantly lower in diabetic than in non\u2010diabetic parotid glands and that diabetes affects protein expression at identical extent in parotid and submandibular glands. The results strengthen the hypothesis that a reduced statherin secretion may be responsible for the higher incidence of oral disorders in diabetic subjects.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01884.x","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T14:39:52Z","timestamp":1321972792000},"page":"360-364","source":"Crossref","is-referenced-by-count":11,"title":["Diabetes reduces statherin in human parotid: immunogold study and comparison with submandibular gland"],"prefix":"10.1111","volume":"18","author":[{"given":"M","family":"Isola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cossu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Diana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Isola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Loy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Solinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MS","family":"Lantini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2007.40.1.029"},{"key":"e_1_2_7_3_1","first-page":"309","article-title":"Structural differences between alcoholic and diabetic parotid sialosis","volume":"10","author":"Carda C","year":"2005","journal-title":"Oral Med Pathol"},{"key":"e_1_2_7_4_1","first-page":"309","article-title":"A Structural and functional salivary disorders in type 2 diabetic patients","volume":"11","author":"Carda C","year":"2006","journal-title":"Oral Med Pathol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00430406"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2000.028005373.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432384"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0352"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.56.2.439-445.1988"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-756-3_1"},{"key":"e_1_2_7_11_1","first-page":"429","article-title":"Effects of streptozotocin\u2010induced diabetes on the rat parotid gland","volume":"51","author":"Hand AR","year":"1984","journal-title":"Lab Invest"},{"key":"e_1_2_7_12_1","first-page":"287","article-title":"Type 2 diabetes mellitus as a conformational disease","volume":"6","author":"Hayden MR","year":"2005","journal-title":"JOP"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2007.00325.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0684.2002.01020.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.00888.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2010.01217.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01725.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(91)90014-L"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7644"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0364"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1326.2001.00118.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1992.tb01809.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.1.329"},{"key":"e_1_2_7_24_1","first-page":"2","article-title":"Buccal alterations in diabetes mellitus","volume":"15","author":"Negrato CA","year":"2010","journal-title":"Diabetol Metab Syndr"},{"key":"e_1_2_7_25_1","first-page":"127","article-title":"Caries, periodontal disease and tooth loss in patients with diabetes mellitus types 1 and 2","volume":"21","author":"Pati\u00f1o Mar\u00edn N","year":"2008","journal-title":"Acta Odontol Latinoam"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070260104"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"5968","DOI":"10.1016\/S0021-9258(18)42650-6","article-title":"Salivary statherin. 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