{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:08:46Z","timestamp":1768320526283,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T00:00:00Z","timestamp":1325116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>18<\/jats:bold>, 365\u2013374<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Patients with Sj\u00f6gren\u2019s syndrome (SS) show aberrant expression of the B cell\u2010related mediators, B cell\u2010activating factor (BAFF), and a proliferation\u2010inducing ligand (APRIL) in serum and salivary glands (SGs). We studied the biological effect of neutralizing these cytokines by local gene transfer of the common receptor transmembrane activator and CAML interactor (TACI) in an animal model of SS.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> A recombinant serotype 2 adeno\u2010associated virus (rAAV2) encoding TACI\u2010Fc was constructed, and its efficacy was tested in the SGs of non\u2010obese diabetic mice. Ten weeks later, SG inflammation was evaluated and serum and SG tissue were analyzed for inflammatory markers including immunoglobulins (Ig) and cytokines.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> AAV2\u2010TACI\u2010Fc gene therapy significantly reduced the number of inflammatory foci in the SG, owing to a decrease in IgD<jats:sup>+<\/jats:sup> cells and CD138<jats:sup>+<\/jats:sup> cells. Moreover, IgG and IgM levels, but not IgA levels, were reduced in the SG. Overall expression of mainly proinflammatory cytokines tended to be lower in AAV2\u2010TACI\u2010Fc\u2010treated mice. Salivary flow was unaffected.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Although local expression of soluble TACI\u2010Fc reduced inflammation and immunoglobulin levels in the SG, further research will have to prove whether dual blockade of APRIL and BAFF by TACI\u2010Fc can provide a satisfying treatment for the clinical symptoms of patients.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01885.x","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T19:07:42Z","timestamp":1323112062000},"page":"365-374","source":"Crossref","is-referenced-by-count":23,"title":["TACI\u2010Fc gene therapy improves autoimmune sialadenitis but not salivary gland function in non\u2010obese diabetic 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