{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:32:39Z","timestamp":1780104759017,"version":"3.54.0"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>18<\/jats:bold>, 375\u2013388<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> The aim of this study was to investigate how T\u2010helper 17 cells (Th17 cells), interleukin (IL)\u201017, and interleukin\u20106 contribute to root resorption during orthodontic tooth movement.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> Fifteen male 6\u2010week\u2010old Wistar rats were subjected to orthodontic force of 10 or 50\u2003g to induce a mesially tipping movement of the upper first molars for 7\u2003days. The expression levels of TRAP, IL\u201017, the IL\u201017 receptor (IL\u201017R), and IL\u20106 proteins were determined in periodontal ligament (PDL) by immunohistochemical analysis. Moreover, the fluorescent localization immunoassay was performed to detect Th17 cells. Furthermore, the effects of IL\u201017 on IL\u20106 release were investigated using human PDL cells <jats:italic>in vitro<\/jats:italic>. The effect of IL\u201017 on osteoclastogenesis was evaluated by TRAP staining, actin ring staining, and the pit formation assay.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The immunoreactivity for Th17, IL\u201017, IL\u201017R, and IL\u20106 was detected in PDL tissue subjected to the orthodontic force on day 7. IL\u201017 increased the release of IL\u20106 from human periodontal ligament cells in a time\u2010dependent manner. Moreover, IL\u201017 stimulated osteoclastogenesis from human osteoclast precursor cells, and these effects were partially suppressed by an anti\u2010IL\u20106 antibody.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These results suggest that Th17 cells may aggravate the process of orthodontically induced inflammatory root resorption.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01886.x","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T19:07:39Z","timestamp":1323112059000},"page":"375-388","source":"Crossref","is-referenced-by-count":48,"title":["T\u2010helper 17 cells mediate the osteo\/odontoclastogenesis induced by excessive orthodontic 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