{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:20:56Z","timestamp":1772104856902,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T00:00:00Z","timestamp":1338940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>18<\/jats:bold>, 501\u2013505<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To investigate the expression and distribution of AQP5 in submandibular acinar cells from sham\u2010 and streptozotocin (STZ)\u2010treated mice in relation to the salivary flow.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Mice were sham or STZ injected. Distribution of AQP5 subcellular expression in submandibular glands was determined by immunohistochemistry. AQP5 labelling indices (LI), reflecting AQP5 subcellular distribution, were determined in acinar cells. Western blotting was performed to determine the expression of AQP5 in submandibular glands. Blood glycaemia and osmolality and saliva flow rates were also determined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> AQP5 immunoreactivity was primarily located at the apical and apical\u2010basolateral membranes of submandibular gland acinar cells from sham\u2010 and STZ\u2010treated mice. No significant differences in AQP5 protein levels were observed between sham\u2010 and STZ\u2010treated mice. Compared to sham\u2010treated mice, STZ\u2010treated mice had significant increased glycaemia, while no significant differences in blood osmolality were observed. Saliva flow rate was significantly decreased in STZ\u2010treated mice as compared to sham\u2010treated mice.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In STZ\u2010treated mice, significant reduction in salivary flow rate was observed without any concomitant modification in AQP5 expression and localization.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2011.01902.x","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T09:12:54Z","timestamp":1325063574000},"page":"501-505","source":"Crossref","is-referenced-by-count":14,"title":["Relationship between aquaporin\u20105 expression and saliva flow in streptozotocin\u2010induced diabetic mice?"],"prefix":"10.1111","volume":"18","author":[{"given":"MS","family":"Soyfoo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Bolaky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Depoortere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Delporte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460804"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel067"},{"key":"e_1_2_7_4_1","first-page":"5","article-title":"Aquaporins in secretory glands and their role in Sjogren\u2019s syndrome","volume":"18","author":"Delporte C","year":"2009","journal-title":"Handb Exp Pharmacol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66990-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/407031"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FMJ04004X6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.19.384"},{"key":"e_1_2_7_9_1","first-page":"1071","article-title":"Abnormal distribution of aquaporin\u20105 in salivary glands in the NOD mouse model for Sjogren\u2019s syndrome","volume":"32","author":"Konttinen YT","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008760200"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR3569.1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.29.20071"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.117815"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22826"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780221"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04140-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02132.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.01.013"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00057.2006"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1601-0825.2011.01902.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1601-0825.2011.01902.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T22:33:20Z","timestamp":1698705200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1601-0825.2011.01902.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,6]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1601-0825.2011.01902.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1601-0825.2011.01902.x","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,6]]}}}