{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:31:22Z","timestamp":1791156682565,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T00:00:00Z","timestamp":1328745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>18,<\/jats:bold> 568\u2013574<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To determine whether a link exists between inflammation and aquaporin\u20105 distribution in submandibular glands from three animal models for Sj\u00f6gren\u2019s syndrome: IQI\/JIC, r1\u0394T\/r2n and non\u2010obese diabetic mice.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Mice of different ages were used. Inflammatory infiltrates were quantified using the focus score. Acinar aquaporin\u20105 subcellular distribution was determined by immunohistochemistry and quantified using labelling indices.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Minor inflammatory infiltrates were present in r1f\/r2n mice. Massive inflammatory infiltrates and acinar destruction were observed in 24\u2010week\u2010old non\u2010obese diabetic mice, 10\u2010and 13\u2010month\u2010old IQI\/JIC mice and some r1\u0394T\/r2n mice. Aquaporin\u20105 immunoreactivity was primarily apical in submandibular glands from 8\u2010 and 24\u2010week\u2010old Balb\/C mice, 8\u2010week\u2010old non\u2010obese diabetic mice, 2\u2010, 4\u2010 and 7\u2010month\u2010old IQI\/JIC mice and r1f\/r2n mice. In contrast, decreased apical aquaporin\u20105 labelling index with concomitant increased apical\u2010basolateral, apical\u2010cytoplasmic and\/or apical\u2010basolateral\u2010cytoplasmic aquaporin\u20105 labelling indices was observed in 24\u2010week\u2010old non\u2010obese diabetic, 10\u2010 and 13\u2010month\u2010old IQI\/JIC and r1\u0394T\/r2n mice with a focus score\u2003\u2265\u20031.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Altered aquaporin\u20105 distribution in submandibular acinar cells from IQI\/JIC, non\u2010obese diabetic and r1\u0394T\/r2n mice with a focus score\u2003\u2265\u20031 appears to be concomitant to the presence of inflammatory infiltrates and acinar destruction.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2012.01909.x","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T07:06:22Z","timestamp":1326783982000},"page":"568-574","source":"Crossref","is-referenced-by-count":30,"title":["Link between inflammation and aquaporin\u20105 distribution in submandibular gland in sj\u00f6gren\u2019s 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