{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:04:00Z","timestamp":1787015040070,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n                    <jats:italic>Oral Diseases<\/jats:italic>\n                    (2012)\n                    <jats:bold>18<\/jats:bold>\n                    , 633\u2013638\n                  <\/jats:p>\n                  <jats:p>Antitumour necrosis factor (TNF\u2010\u03b1) therapy has a potential to benefit patients with oral lesions of Crohn\u2019s disease (CD) and patients with orofacial granulomatosis (OFG). The most appropriate use would appear to be in patients with severe or multisystem features, where other available agents have failed or have been associated with adverse effects. TNF\u2010\u03b1 antagonists (infliximab in particular) have a role in the management of orofacial CD and OFG, but potential adverse effects of TNF\u2010\u03b1 antagonists include acute infusion reactions, infection and increased risk of malignancy. Thus, a full risk\u2013benefit analysis is indicated, with patient selection, use and subsequent monitoring coordinated with gastroenterologists with appropriate training and experience in biological therapies.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2012.01918.x","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T22:14:41Z","timestamp":1331849681000},"page":"633-638","source":"Crossref","is-referenced-by-count":39,"title":["Biologics in oral medicine: oral Crohn\u2019s disease and orofacial 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