{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:16:38Z","timestamp":1777540598658,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T00:00:00Z","timestamp":1332288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>18<\/jats:bold>, 655\u2013660<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To compare the effects of sodium lauryl sulfate (SLS)\u2010free and SLS\u2010containing dentifrice in patient with recurrent aphthous stomatitis (RAS).<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> The design of this study was a double\u2010blind crossover trial. The 90 subjects were divided into three groups: group I used SLS\u2010free (a commercially available SLS\u2010free dentifrice) and SLS\u2010A (SLS\u2010free\u2003+\u20031.5% SLS), group II used SLS\u2010A and SLS\u2010B (a commercially available 1.5% SLS\u2010containing dentifrice), and group III used SLS\u2010free and SLS\u2010B. The subjects used one of the two assigned dentifrices for 8\u2003weeks and then the other for the following 8\u2003weeks. The order of the dentifrices used was selected at random, and there was a 2\u2010week washout period between the two phases. The clinical parameters (number of ulcers, number of episodes, duration of ulcers, mean pain score) were compared between the two phases for each group.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The number of ulcers and episodes did not differ significantly between SLS\u2010A, SLS\u2010B, and SLS\u2010free. Only duration of ulcers and mean pain score was significantly decreased during the period using SLS\u2010free.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Although SLS\u2010free did not reduce the number of ulcers and episodes, it affected the ulcer\u2010healing process and reduces pain in daily lives in patients with RAS.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2012.01920.x","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T19:42:11Z","timestamp":1329939731000},"page":"655-660","source":"Crossref","is-referenced-by-count":41,"title":["Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: a randomized controlled clinical 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