{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:47:54Z","timestamp":1771073274146,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T00:00:00Z","timestamp":1332892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic>(2012)<jats:bold>18<\/jats:bold>, 680\u2013691<\/jats:p><jats:p><jats:bold>Objective:\u00a0<\/jats:bold>Amisulpride is suggested for treatment of clozapine\u2010induced sialorrhea. However, objective measurements of its effectiveness are lacking and, preclinically, amisulpride has no effect. We currently hypothesise that amisulpride acts by reducing the nervous\u2010 rather than the clozapine\u2010driven salivary secretion.<\/jats:p><jats:p><jats:bold>Material and Methods:\u00a0<\/jats:bold>Effects of intravenous amisulpride (as well as of clozapine and raclopride, a dopamine D2\/D3 antagonist) were investigated in rats, including those subjected to chronic preganglionic parasympathetic denervation (submandibular glands) or combined postganglionic parasympathetic and sympathetic denervation (parotid glands). In duct\u2010cannulated glands, secretion was evoked reflexly, at low and maximum flow rates, and by electrical stimulation of the parasympathetic and sympathetic innervations, and administration of autonomimetics (including substance P).<\/jats:p><jats:p><jats:bold>Results:\u00a0<\/jats:bold>Unlike clozapine, amisulpride had no effect on the reflexly evoked secretion at maximum rate. With respect to reflex secretion at low rate and to the secretion evoked by muscarinic, \u03b1\u2010adrenergic, \u03b2\u2010adrenergic and substance P receptors, amisulpride (in contrast to raclopride) dose dependently potentiated the responses. Amisulpride had no effect on gland blood flow.<\/jats:p><jats:p><jats:bold>Conclusions:\u00a0<\/jats:bold>No support for any inhibitory influence of amisulpride was found. Conversely, amisulpride universally enhanced secretion, suggesting that amisulpride is a potential drug for dry\u2010mouth treatment. The mechanism behind the potentiation is currently unknown.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2012.01926.x","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T19:48:32Z","timestamp":1330976912000},"page":"680-691","source":"Crossref","is-referenced-by-count":14,"title":["Atypical antipsychotics \u2013 effects of amisulpride on salivary secretion and on clozapine\u2010induced sialorrhea"],"prefix":"10.1111","volume":"18","author":[{"given":"T","family":"Godoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Riva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1521-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1991.tb01243.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.1993.50"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000061125"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00296-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600290"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680010901"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00967-X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017283"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000061091"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1998.sp004150"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000061117"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000061124"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8602199"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.201249.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509356055"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2009.00696.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(80)90060-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2011.00832.x"},{"key":"e_1_2_8_21_1","volume-title":"The pharmacological basis of therapeutics","author":"Goodman and Gilman","year":"1995"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079902125000363"},{"key":"e_1_2_8_23_1","volume-title":"Anatomy of the rat","author":"Greene EC","year":"1955"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308323"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/clinchem\/28.11.2201","article-title":"Mechanism of action of human pancreatic and salivary alpha\u2010amylase on alpha\u20104\u2010nitrophenyl maltoheptaoside substrate","volume":"28","author":"H\u00e4gele EO","year":"1982","journal-title":"Clin Chem"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1986.tb11147.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.032441"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2009.00632.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498258509045890"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90778-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2010.527370"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.05.004"},{"key":"e_1_2_8_33_1","first-page":"102","volume-title":"Salivary gland disorders and diseases: diagnosis and management","author":"Laskawi R","year":"2011"},{"key":"e_1_2_8_34_1","first-page":"101","article-title":"Human submandibular glands treated in vitro with amisulpride. 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