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We investigated the following controversial topics: (i) Do we have reliable ways of assessing saliva production? (ii) How important are the quantity and quality of saliva? (iii) Are only anti\u2010SSA\/Ro and anti\u2010SSB\/La relevant for the diagnosis of SjS? (iv) Are the American\u2010European Consensus criteria (AECC) the best way to diagnose SjS? Results from literature searches suggested the following: (i) Despite the fact that numerous tests are available to assess salivation rates, direct comparisons among them are scarce with little evidence to suggest one best test. (ii) Recent developments highlight the importance of investigating the composition of saliva. However, more research is needed to standardize the methods of analysis and collection and refine the quality of the accumulating data. (iii) In addition to anti\u2010Ro\/La autoantibodies, anti \u03b1\u2010fodrin IgA and anti\u2010MR3 autoantibodies seem to be promising diagnostic markers of SjS, but more studies are warranted to test their sensitivity and specificity. (iv) AECC are classification, not diagnostic criteria. Moreover, recent innovations have not been incorporated into these criteria. Consequently, treatment directed to patients diagnosed using the AECC might exclude a significant proportion of patients with SjS.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2012.01930.x","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:33:50Z","timestamp":1332808430000},"page":"46-58","source":"Crossref","is-referenced-by-count":13,"title":["Urban legends series: Sj\u00f6gren\u2019s 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