{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:02:07Z","timestamp":1789387327375,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T00:00:00Z","timestamp":1337731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>18<\/jats:bold>, 763\u2013770<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To investigate the effectiveness of short\u2010term adjunctive subantimicrobial dose doxycycline (SDD) treatment in patients with diabetes mellitus type 2 and chronic periodontitis (CP).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty\u2010four patients with CP and type 2 diabetes mellitus were included in the placebo\u2010controlled, double\u2010blind study. After scaling and root planing (SRP), patients were randomly assigned to two groups, receiving either SDD or placebo bid for 3\u2003months. The probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), approximal plaque index, glycated hemoglobin (HbA1c) level were recorded and gingival crevicular fluid (GCF) samples were collected at baseline and after 3\u2010month therapy for the estimation of matrix metalloproteinase\u20108 levels.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Clinical attachment level, PD, and BOP improved significantly in both groups after therapy (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). The statistically significant difference between the two groups after the therapy was observed only in PD in tooth sites with initial PD\u2003\u2265\u20034\u2003mm (SRP\u2003+\u2003placebo: 3.41\u2003\u00b1\u20030.6\u2003mm <jats:italic>vs<\/jats:italic> SRP\u2003+\u2003SDD: 2.92\u2003\u00b1\u20030.5\u2003mm, <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). GCF matrix metalloproteinase\u20108 levels were significantly reduced only in SRP\u2003+\u2003SDD group (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.01). There were no changes in HbA1c levels after therapy.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The short\u2010term administration of SDD gives significant benefit at tooth sites with moderate disease (PD\u2003\u2265\u20034\u2003mm) when compared to SRP alone in patients with diabetes and CP.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2012.01943.x","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T22:10:16Z","timestamp":1335305416000},"page":"763-770","source":"Crossref","is-referenced-by-count":33,"title":["Efficacy of short\u2010term adjunctive subantimicrobial dose doxycycline in diabetic patients \u2013 randomized 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