{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:24:37Z","timestamp":1778217877772,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>19<\/jats:bold>, 65\u201372<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Heat\u2010shock protein 27 (<jats:italic>hsp27<\/jats:italic>) has been implicated in several biological events. In this experimental study, we aimed at analysing, for the first time, the expression of <jats:italic>hsp27<\/jats:italic> in the diverse stages of oral lichen planus (OLP) lesions.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> Thirty\u2010six biopsy specimens of patients with OLP and 10 of healthy patients were selected. OLP specimens were divided into three groups: G1 \u2013 moderate or mildly active OLP; G2 \u2013 active or moderately active atrophic OLP; G3 \u2013 mild or inactive atrophic OLP. <jats:italic>Hsp27<\/jats:italic> expression was analysed by immunohistochemistry (staining intensity and percentage of stained cells), and results of staining were compared between the different groups. Gender, age and anatomical location were also studied.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In the basal layer, an increase of <jats:italic>hsp27<\/jats:italic> expression in both G2 and G3 was observed when compared to G1 and control group. In contrast, a decrease of <jats:italic>hsp27<\/jats:italic> expression in the superficial layer was observed in all groups when compared to control group.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The increased expression of <jats:italic>Hsp27<\/jats:italic> in the basal layer observed during the OLP evolution and the less staining in the superficial layers in all cases of OLP suggest that <jats:italic>hsp27<\/jats:italic> may have a role in the OLP pathogenesis.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2012.01951.x","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T18:37:46Z","timestamp":1338489466000},"page":"65-72","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of the expression of heat\u2010shock protein 27 in patients with oral lichen 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