{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T12:34:40Z","timestamp":1767098080868},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T00:00:00Z","timestamp":1342137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:italic>Oral Diseases<\/jats:italic> (2012) <jats:bold>19<\/jats:bold>, 85\u201391<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To analyze the expression and distribution patterns of mature dendritic cells (mDCs) and immature DCs (imDCs) in radicular cysts (RCs), dentigerous cysts (DtCs), and keratocystic odontogenic tumors (KCOTs).<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> Forty\u2010nine odontogenic cystic lesions (OCLs) (RCs, <jats:italic>n<\/jats:italic>\u2003=\u200320; DtCs, <jats:italic>n<\/jats:italic>\u2003=\u200315; KCOTs, <jats:italic>n<\/jats:italic>\u2003=\u200314) were assessed using the following markers: S100, CD1a and CD207 for imDCs; and CD83 for mDCs.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Almost all cases were S100, CD1a, and CD207 positive, whereas 63% were CD83 positive. RCs presented greater number of immunostained cells, followed by DtCs, and KCOTs. The number of S100+ cells was greater than both CD1a+ and CD207+ cells (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.001), which showed approximately similar amounts, followed by lower number of CD83+ cells (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.001) in each OCL type. Different from S100+ cells, both CD1a+ and CD207+ cells on the epithelium (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05) and CD83+ cells on the capsule (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05) were preferentially observed. In RCs, significant correlation was found between the thickness epithelium with S100+ and CD1a+ cells, and between the degree of inflammation with CD83+ cells.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Dendritic cell populations in OCLs can be phenotypically heterogeneous, and it could represent distinct lineages and\/or functional stages. It is suggested that besides DC\u2010mediated immune cell interactions, DC\u2010mediated tissue differentiation and maintenance in OCLs should also be considered.<\/jats:p>","DOI":"10.1111\/j.1601-0825.2012.01960.x","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T12:55:44Z","timestamp":1340888144000},"page":"85-91","source":"Crossref","is-referenced-by-count":6,"title":["Immunophenotypic characterization and distribution of dendritic cells in odontogenic cystic lesions"],"prefix":"10.1111","volume":"19","author":[{"given":"FTC","family":"Matos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VHT","family":"Rizo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LY","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Tirapelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YTC","family":"Silva\u2010Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OP","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JE","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,13]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"71","article-title":"Langerhans cells in odontogenic cysts. 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