{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:57:04Z","timestamp":1793393824747,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T00:00:00Z","timestamp":1159315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p> <jats:bold>Mice of the FVB\/N strain are severely visual impaired as a result of tyrosinase gene defects, leading to a deficiency of the key enzyme for melanin synthesis in skin and eye and of cyclic guanosine monophosphate phosphodiesterase gene defects, which results in albinism (Tyr<jats:sup>c\/c<\/jats:sup>) and retinal degeneration (Pde6b<jats:sup>rd1\/rd1<\/jats:sup>), respectively. Nevertheless, FVB\/N mice are commonly used for the generation of transgenic animals because of their large, strong pronuclei and high breeding performance. However, due to visual impairment of the FVB\/N animals, the resulting transgenic animals cannot be used in tests that depend on vision, including tests of cognitive behavior. Therefore, we have bred a sighted version of the FVB\/N strain by an outcross between FVB\/N and 129P2\/OlaHsd, followed by repeated backcrosses to FVB\/N mice while selecting against albinism and homozygosity of the retinal degeneration mutation. After 11 generations of backcrossing, sighted animals were intercrossed to generate the congenic FVB.129P2\u2010Pde6b<jats:sup>+<\/jats:sup> Tyr<jats:sup><jats:italic>c\u2010ch<\/jats:italic><\/jats:sup>\/Ant strain, which is pigmented (Tyr<jats:sup><jats:italic>c\u2010ch<\/jats:italic><\/jats:sup>\/<jats:sup><jats:italic>c\u2010ch<\/jats:italic><\/jats:sup>) and devoid of the genetic predisposition to retinal degeneration. The accurate visual abilities of the FVB.129P2\u2010Pde6b<jats:sup>+<\/jats:sup> Tyr<jats:sup><jats:italic>c\u2010ch<\/jats:italic><\/jats:sup>\/Ant mice, for which we propose the name FVBS\/Ant, demonstrated a clear visual evoked potential in the presence of normal eye histology and improved performance in the Morris water maze test.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1601-183x.2006.00282.x","type":"journal-article","created":{"date-parts":[[2006,11,3]],"date-time":"2006-11-03T09:07:45Z","timestamp":1162544865000},"page":"552-557","source":"Crossref","is-referenced-by-count":40,"title":["FVB.129P2\u2010Pde6b<sup>+<\/sup> Tyr<sup><i>c\u2010ch<\/i><\/sup>\/Ant, a sighted variant of the FVB\/N mouse strain suitable for behavioral analysis"],"prefix":"10.1111","volume":"6","author":[{"given":"V.","family":"Errijgers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Van Dam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Gantois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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