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Nevertheless, pattern of handedness and degree of lateralization have not been explicitly tested in BPD. We measured handedness, footedness and relative manual dexterity in a sample of 47 families comprising BPD probands and their bipolar\u2010spectrum and unaffected relatives (<jats:italic>N <\/jats:italic>= 240). The BPD I sample (<jats:italic>N <\/jats:italic>= 55) was significantly more lateralized on handedness, footedness and relative manual dexterity than their unaffected relatives (<jats:italic>N <\/jats:italic>= 66). They were also more lateralized than their relatives with other psychiatric diagnoses. No evidence of excess mixed handedness or footedness was observed in the BPD I sample. We raise the possibility that schizophrenia and BPD I differ in that disproportionate left\u2010hemisphere dominance in BPD I is associated with right\u2010hemisphere dysfunction leading to deficits in emotional regulation. Given our results, we hypothesized that degree of lateralization may be a phenotypic marker or endophenotype for BPD I. We therefore conducted a family\u2010based genetic association analysis with this quantitative trait. Relative hand skill was significantly associated with a functional variant in the catechol\u2010<jats:italic>O<\/jats:italic>\u2010methyltransferase gene. We speculate that this polymorphism may influence brain lateralization.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1601-183x.2006.00299.x","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T18:40:27Z","timestamp":1171651227000},"page":"698-705","source":"Crossref","is-referenced-by-count":38,"title":["Lateralization of hand skill in bipolar affective disorder"],"prefix":"10.1111","volume":"6","author":[{"given":"J.","family":"Savitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Van Der 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