{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:10:51Z","timestamp":1790943051075,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2008,1,3]],"date-time":"2008-01-03T00:00:00Z","timestamp":1199318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p> <jats:bold>Accumulating evidence points to an important role of intraneuronal A\u03b2 as a trigger of the pathological cascade of events leading to neurodegeneration and eventually to Alzheimer\u2019s disease (AD) with its typical clinical symptoms, like memory impairment and change in personality. As a new concept, intraneuronal accumulation of A\u03b2 instead of extracellular A\u03b2 deposition has been introduced to be the disease\u2010triggering event in AD. The present review compiles current knowledge on the amyloid precursor protein (APP)\/PS1KI mouse model with early and massive intraneuronal A\u03b242 accumulation: (1) The APP\/PS1KI mouse model exhibits early robust brain and spinal cord axonal degeneration and hippocampal CA1 neuron loss. (2) At the same time\u2010point, a dramatic, age\u2010dependent reduced ability to perform working memory and motor tasks is observed. (3) The APP\/PS1KI mice are smaller and show development of a thoracolumbar kyphosis, together with an incremental loss of body weight. (4) Onset of the observed behavioral alterations correlates well with robust axonal degeneration in brain and spinal cord and with abundant hippocampal CA1 neuron loss.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1601-183x.2007.00372.x","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T16:30:39Z","timestamp":1282235439000},"page":"6-11","source":"Crossref","is-referenced-by-count":50,"title":["Review on the APP\/PS1KI mouse model: intraneuronal A\u03b2 accumulation triggers axonopathy, neuron loss and working memory impairment"],"prefix":"10.1111","volume":"7","author":[{"given":"T. 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