{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:26:37Z","timestamp":1774869997252,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,1,30]],"date-time":"2010-01-30T00:00:00Z","timestamp":1264809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p> <jats:bold>Integrins are heterodimeric transmembrane cell adhesion receptors that are essential for a wide range of biological functions via cell\u2013matrix and cell\u2013cell interactions. Recent studies have provided evidence that some of the subunits in the integrin family are involved in synaptic and behavioral plasticity. To further understand the role of integrins in the mammalian central nervous system, we generated a postnatal forebrain and excitatory neuron\u2010specific knockout of \u03b18\u2010integrin in the mouse. Behavioral studies showed that the mutant mice are normal in multiple hippocampal\u2010dependent learning tasks, including a T\u2010maze, non\u2010match\u2010to\u2010place working memory task for which other integrin subunits like \u03b13\u2010 and \u03b21\u2010integrin are required. In contrast, mice mutant for \u03b18\u2010integrin exhibited a specific impairment of long\u2010term potentiation (LTP) at Schaffer collateral\u2013CA1 synapses, whereas basal synaptic transmission, paired\u2010pulse facilitation and long\u2010term depression (LTD) remained unaffected. Because LTP is also impaired in the absence of \u03b13\u2010integrin, our results indicate that multiple integrin molecules are required for the normal expression of LTP, and different integrins display distinct roles in behavioral and neurophysiological processes like synaptic plasticity.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1601-183x.2010.00569.x","type":"journal-article","created":{"date-parts":[[2010,1,30]],"date-time":"2010-01-30T09:42:09Z","timestamp":1264844529000},"page":"402-410","source":"Crossref","is-referenced-by-count":28,"title":["\u03b18\u2010Integrins are required for hippocampal long\u2010term potentiation but not for hippocampal\u2010dependent learning"],"prefix":"10.1111","volume":"9","author":[{"given":"C.\u2010S.","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Dragatsis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Rosenmund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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