{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:34:58Z","timestamp":1792305298436,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T00:00:00Z","timestamp":1348099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:bold>The aim was to study a broader phenotype of language\u2010related diagnoses and problems in three generations of relatives of children with specific language impairment (<jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content>). Our study is based on a family history interview of the parents of 59 children with <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> and of 100 matched control children, exploring the prevalence of problems related to language, reading, attention, school achievement and social communication as well as diagnoses such as attention\u2010deficit hyperactivity disorder (<jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>), autism, Asperger syndrome, dyslexia, mental retardation, cleft palate and stuttering. The results show a spectrum of language\u2010related problems in families of <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> children. In all three generations of <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> relatives, we found significantly higher prevalence rates of language, literacy and social communication problems. The risk of one or both parents having language\u2010related diagnoses or problems was approximately six times higher for the children with <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> (85%) than for the control children (13%) (odds ratio\u2009=\u200937.2). We did not find a significantly higher prevalence of the <jats:italic>diagnoses<\/jats:italic> <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>, autism or Asperger syndrome in the relatives of the children with <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content>. However, significantly more parents of the children with <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> had <jats:italic>problems<\/jats:italic> with attention\/hyperactivity when compared with the parents of controls. Our findings suggest common underlying mechanisms for problems with language, literacy and social communication, and possibly also for attention\/hyperactivity symptoms.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1601-183x.2012.00841.x","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T16:22:51Z","timestamp":1346170971000},"page":"921-927","source":"Crossref","is-referenced-by-count":27,"title":["Family history interview of a broad phenotype in specific language impairment and matched controls"],"prefix":"10.1111","volume":"11","author":[{"given":"N.","family":"Kalnak","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Astrid Lindgren Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Peyrard\u2010Janvid","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Nutrition Karolinska Institutet  Stockholm 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