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Reduced expression of the neurotrophin brain\u2010derived neurotrophic factor (<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>) in striatal afferents may play a role in neuronal loss. How progressive loss of<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>expression in different cortical or subcortical afferents contributes to striatal atrophy and behavioral dysfunction in<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>is not known, and may best be determined in animal models. We compared age\u2010dependent alterations of<jats:styled-content style=\"fixed-case\">BDNF mRNA<\/jats:styled-content>expression in major striatal afferents from the cerebral cortex, thalamus and midbrain in the<jats:styled-content style=\"fixed-case\">R6\/2<\/jats:styled-content>transgenic mouse model of<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>. Corresponding changes in striatal morphology were quantified using unbiased stereology. Changes in motor behavior were measured using an open field, grip strength monitor, limb clasping and a rotarod apparatus.<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>expression in cortical limbic and midbrain striatal afferents is reduced by age 4\u2009weeks, prior to onset of motor abnormalities.<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>expression in motor cortex and thalamic afferents is reduced by 6 weeks, coinciding with early motor dysfunction and reduced striatum volume.<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>loss in afferents progresses until death at 13\u201315\u2009weeks, correlating with progressive striatal neuronal loss and motor abnormalities. Mutant huntingtin protein expression in<jats:styled-content style=\"fixed-case\">R6\/2<\/jats:styled-content>mice results in progressive loss of<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>in both cortical and subcortical striatal afferents.<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>loss in limbic and dopaminergic striatal inputs may contribute to cognitive\/psychiatric dysfunction in<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>. Subsequent<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>loss in cortical motor and thalamic afferents may accelerate striatal degeneration, resulting in progressive involuntary movements.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1601-183x.2012.00858.x","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T14:13:07Z","timestamp":1348495987000},"page":"108-124","source":"Crossref","is-referenced-by-count":51,"title":["Relationship between<scp>BDNF<\/scp>expression in major striatal afferents, striatum morphology and motor behavior in the<scp>R6\/2<\/scp>mouse model of Huntington's disease"],"prefix":"10.1111","volume":"12","author":[{"given":"P.","family":"Samadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boutet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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