{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:18:41Z","timestamp":1791134321449,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The aim of this study was to evaluate the efficacy of topical subgingival application of doxycycline hyclate (DH) gel adjunctive to non\u2010surgical periodontal therapy on gingival crevicular fluid (GCF) matrix metalloproteinase (MMP)\u20108 levels in chronic and aggressive periodontitis patients. Forty teeth of 10 chronic periodontitis patients and 32 teeth of eight aggressive periodontitis patients were screened for 6\u2003months. Scaling and root planing (SRP) was applied to the control sites and DH gel adjunctive to SRP was applied to the test sites of each patient simultaneously. GCF MMP\u20108 levels were analysed at baseline, 7\u2003days; and at 1, 3 and 6\u2003months by Sandwich Elisa Method. At 1, 3 and 6\u2003months, probing depth (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0051) and plaque scores and bleeding on probing values (<jats:italic>P<\/jats:italic>\u2003=\u20030.000) significantly decreased in each group when compared with the baseline, but there was no statistically significant difference between the test and control sites. GCF MMP\u20108 levels reduced presenting statistically significant differences on 7\u2003days, 1, 3 and 6\u2003months in four of the groups (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05); however, intergroup differences were not statistically significant. Developing functional and immunological\u2010based chair\u2010side MMP tests might serve as useful adjunctive diagnostic tools when monitoring the effects of DH gel application.<\/jats:p>","DOI":"10.1111\/j.1601-5037.2006.00174.x","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T20:18:26Z","timestamp":1153253906000},"page":"114-121","source":"Crossref","is-referenced-by-count":27,"title":["The effect of topical doxycycline usage on gingival crevicular fluid MMP\u20108 levels of chronic and aggressive periodontitis patients: a pilot 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