{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:21:41Z","timestamp":1792070501645,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T00:00:00Z","timestamp":1177372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>  <jats:italic>Introduction:\u2002<\/jats:italic>In implants, maintenance assumes an important role. The role of chlorhexidine (CHX) is well known in maintenance, while only limited evidence exists on the practical use of hyaluronic acid (HA). The objective of this study was to compare the health status of the peri\u2010implant complex (hard and soft tissues surrounding the implant) during the healing period of immediate function implants, using HA or CHX gels in the patient's maintenance protocol.<jats:italic>Study population and methodology:\u2002<\/jats:italic>Thirty complete edentulous patients, with four immediate function Br\u00e5nemark System implants placed in the mandible (total of 120 implants), were randomly assigned to two groups (HA and CHX) using only these two chemicals in their daily implant self\u2010care. Both groups were followed up for 6\u2003months, with clinical observations on the 10th day, 2\u2003months, 4\u2003months and 6\u2003months post\u2010surgically.<jats:italic>Results:\u2002<\/jats:italic>During the course of the study, HA and CHX produced good results in maintaining a healthy peri\u2010implant complex in immediate function implants for complete rehabilitations in the edentulous mandible. Statistically significant differences were found in favour of the HA group in the modified bleeding index on the second observation (<jats:italic>P<\/jats:italic>\u2003=\u20030.003). The difference was more marked in the axial implants placed in the fifth sextant (<jats:italic>P<\/jats:italic>\u2003=\u20030.05). Correlation coefficient between plaque and bleeding index revealed a potentially better result for CHX at 6\u2003months.<jats:italic>Conclusion:\u2002<\/jats:italic>The findings point out the importance of a maintenance protocol in immediate function implants. Both chemicals are valid tools for implant maintenance. The authors suggest that it might be advantageous to administer HA in the first 2\u2003months and CHX between 2 and 6\u2003months.<\/jats:p>","DOI":"10.1111\/j.1601-5037.2007.00239.x","type":"journal-article","created":{"date-parts":[[2007,5,6]],"date-time":"2007-05-06T08:51:37Z","timestamp":1178441497000},"page":"87-94","source":"Crossref","is-referenced-by-count":36,"title":["Peri\u2010implant maintenance of immediate function implants: a pilot study comparing hyaluronic acid and chlorhexidine"],"prefix":"10.1111","volume":"5","author":[{"given":"M","family":"De Ara\u00fajo Nobre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Cintra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Mal\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2000.tb00004.x"},{"key":"e_1_2_5_3_2","first-page":"644","article-title":"Implant maintenance: debridement and peri\u2010implant home care","volume":"12","author":"Bauman GR","year":"1991","journal-title":"Compendium"},{"key":"e_1_2_5_4_2","first-page":"11","article-title":"Control of peri\u2010implant inflammation","volume":"3","author":"Hillenburg KL","year":"1991","journal-title":"Pract Periodontics Aesthet Dent"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130101.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/08959374990130012001"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1061-3315(18)30041-6"},{"key":"e_1_2_5_8_2","first-page":"1","article-title":"The role of hyaluronic acid in the management of periodontal disease","volume":"36","author":"Rabasseda X","year":"2000","journal-title":"Drugs Today"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1999.00079.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.12968\/denu.2002.29.3.144","article-title":"Hyaluronan and its potential role in periodontal healing","volume":"29","author":"Moseley R","year":"2002","journal-title":"Dental Update"},{"key":"e_1_2_5_11_2","first-page":"747","article-title":"Antiproliferative effect of topic hyaluronic acid gel. Study in gingival biopsies of patients with periodontal disease","volume":"17","author":"Mesa FL","year":"2002","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_12_2","first-page":"1","article-title":"Hyaluronic acid in the topical treatment of gingival inflammations: preliminary clinical trial","volume":"3","author":"Vangelisti R","year":"1997","journal-title":"Transl Attualit\u00e0 Terapeutica Int"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.300203.x"},{"key":"e_1_2_5_14_2","first-page":"1","article-title":"Double\u2010blind clinical trial vs. Placebo of a new sodium\u2010hyaluronate\u2010based gingival gel","volume":"4","author":"Pagnacco O","year":"1997","journal-title":"Transl Attualit\u00e0 Terapeutica Int"},{"key":"e_1_2_5_15_2","first-page":"5","article-title":"In vitro study of chlorhexidine resistance in subgingival bacteria","volume":"25","author":"Kamagate A","year":"2002","journal-title":"Odontostomatol Trop"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-002-0168-1"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb00050.x"},{"key":"e_1_2_5_18_2","first-page":"637","article-title":"Antiseptic agents: chlorhexidine","volume":"23","author":"Salas Campos L","year":"2000","journal-title":"Rev Enferm"},{"key":"e_1_2_5_19_2","first-page":"5","article-title":"Chlorhexidine","volume":"50","author":"Moshrefi A","year":"2002","journal-title":"J West Soc Periodontol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2003.tb00010.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(98)70192-1"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1987.tb00298.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1990.010105.x"},{"key":"e_1_2_5_24_2","first-page":"60","volume-title":"Osteointegrazione e Carico Immediate. Fondamenti Biologici e Applicazioni Cliniche","author":"Mal\u00f3 P","year":"2002"},{"key":"e_1_2_5_25_2","first-page":"10","article-title":"Locally delivered antimicrobials in periodontal treatment","volume":"81","author":"John V","year":"2002","journal-title":"J Indiana Dent Assoc"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020204.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345920710090701"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.10.1118"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2004.tb00283.x"},{"key":"e_1_2_5_30_2","first-page":"94","article-title":"Overdentures covering natural roots. The use of chlorhexidine gel","volume":"107","author":"Hendrikx MJ","year":"2000","journal-title":"Ned Tijdschr Tandheelkd"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1994.050409.x"},{"key":"e_1_2_5_32_2","first-page":"107","article-title":"Effects of subgingival chlorhexidine irrigation on peri\u2010implant maintenance","volume":"10","author":"Felo A","year":"1997","journal-title":"Am J Dent"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1998.tb00266.x"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.4.370"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1994.tb00078.x"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02380.x"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00360-3"},{"key":"e_1_2_5_38_2","first-page":"201","article-title":"Contribution of parodium gel in an experimental model of human gingival inflammation","volume":"104","author":"Boisnic S","year":"2003","journal-title":"Rev Stomatol Chir Maxillofac"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2002.29.3.144"},{"key":"e_1_2_5_40_2","first-page":"399","article-title":"Chlorhexidine varnishes prevent gingivitis in adolescents","volume":"67","author":"Bretz WA","year":"2000","journal-title":"ASDC J Den Child"}],"container-title":["International Journal of Dental Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1601-5037.2007.00239.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1601-5037.2007.00239.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:20:21Z","timestamp":1697055621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1601-5037.2007.00239.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,24]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1111\/j.1601-5037.2007.00239.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1601-5037.2007.00239.x","archive":["Portico"],"relation":{},"ISSN":["1601-5029","1601-5037"],"issn-type":[{"value":"1601-5029","type":"print"},{"value":"1601-5037","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,24]]}}}