{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:55:09Z","timestamp":1780048509435,"version":"3.53.1"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"unspecified","delay-in-days":1119,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:sec id=\"S0924270800026351_sec1\"><jats:title\/><jats:p><jats:bold>Objectives:<\/jats:bold>Bipolar disorder (BD) is a mental illness associated with higher rates of suicide. The present study aims to investigate the brain mitochondrial respiratory chain activity in an animal model of mania induced by ouabain.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270800026351_sec2\" sec-type=\"methods\"><jats:title\/><jats:p><jats:bold>Methods:<\/jats:bold>Adult male Wistar rats received a single intracerebroventricular administration of ouabain (10<jats:sup>\u22123<\/jats:sup>and 10<jats:sup>\u22122<\/jats:sup>M) or vehicle. Locomotor activity was measured using the open field test. Mitochondrial respiratory chain activity was measured in the brain of rats 1 h and 7 days after ouabain administration.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270800026351_sec3\" sec-type=\"results\"><jats:title\/><jats:p><jats:bold>Results:<\/jats:bold>Our results showed that spontaneous locomotion was increased 1 h and 7 days after ouabain administration. Complexes I, III and IV activities were increased in the prefrontal cortex, hippocampus and striatum immediately after the administration of ouabain, at the concentration of 10<jats:sup>\u22123<\/jats:sup>and 10<jats:sup>\u22122<\/jats:sup>M. Moreover, complex II activity was increased only in the prefrontal cortex at the concentration of 10<jats:sup>\u22122<\/jats:sup>M. On the other hand, no significant alterations were observed in complex I activity 7 days after ouabain administration. However, an increase in complexes II, III and IV activities was observed only in the prefrontal cortex at the concentration of 10<jats:sup>\u22122<\/jats:sup>M.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270800026351_sec4\" sec-type=\"conclusion\"><jats:title\/><jats:p><jats:bold>Conclusion:<\/jats:bold>Our findings suggest an increase in the activities of mitochondrial respiratory chain in this model of mania. A possible explanation is that these findings occur as a rebound effect trying to compensate for a decrease of ATP deprivation in BD. The present findings suggest that this model may present good face validity and a limitation in construct validity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1601-5215.2011.00543.x","type":"journal-article","created":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T02:45:33Z","timestamp":1300157133000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Mitochondrial respiratory chain activity in an animal model of mania induced by ouabain"],"prefix":"10.1017","volume":"23","author":[{"given":"Tiago P.","family":"Freitas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine T.","family":"Rezin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiane 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