{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:04:10Z","timestamp":1648782250908},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"unspecified","delay-in-days":753,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec id=\"S0924270800026181_sec1\"><jats:title \/><jats:p><jats:bold>Objective:<\/jats:bold> MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) is a neurodegenerative disorder caused by mitochondrial dysfunction. Multiple systems of the body, including cognitive function and heart conduction, can be affected by this disorder. We report a case with global cognitive impairment.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270800026181_sec2\" sec-type=\"methods\"><jats:title \/><jats:p><jats:bold>Method:<\/jats:bold> A single-case report.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270800026181_sec3\" sec-type=\"results\"><jats:title \/><jats:p><jats:bold>Results:<\/jats:bold> The patient got improved cognitive function, especially visuospatial function, under coenzyme Q10 treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270800026181_sec4\" sec-type=\"conclusion\"><jats:title \/><jats:p><jats:bold>Conclusion:<\/jats:bold> First, coenzyme Q10 may give some benefit to control MELAS. Second, cognitive functions and intellectual abilities decline with disease progression. Routine neuropsychological tests should be performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1601-5215.2011.00620.x","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T03:53:20Z","timestamp":1320119600000},"page":"186-188","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Regain of visuospatial capacity after coenzyme Q10 in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes: a case report"],"prefix":"10.1017","volume":"24","author":[{"given":"Che-Sheng","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Liang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Ern","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ti","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"S0924270800026181_ref018","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.5.884"},{"key":"S0924270800026181_ref017","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2010.53.5.644"},{"key":"S0924270800026181_ref016","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700075"},{"key":"S0924270800026181_ref015","first-page":"61","article-title":"Overview on visceral manifestations of mitochondrial disorders.","volume":"64","author":"Finsterer","year":"2006","journal-title":"Neth J Med"},{"key":"S0924270800026181_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1991.tb03962.x"},{"key":"S0924270800026181_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90194-4"},{"key":"S0924270800026181_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90112-3"},{"key":"S0924270800026181_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1991.tb03962.x"},{"key":"S0924270800026181_ref008","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314013"},{"key":"S0924270800026181_ref006","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.8.1275"},{"key":"S0924270800026181_ref002","first-page":"225","article-title":"Clinical aspects of mitochondrial encephalomyopathies.","volume":"8","author":"Shapira","year":"1993","journal-title":"International Pediatrics"},{"key":"S0924270800026181_ref001","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160409"},{"key":"S0924270800026181_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.02.347"},{"key":"S0924270800026181_ref003","doi-asserted-by":"publisher","DOI":"10.1038\/348651a0"},{"key":"S0924270800026181_ref013","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnf.0000137862.67131.bf"},{"key":"S0924270800026181_ref007","doi-asserted-by":"publisher","DOI":"10.1080\/000486700286"},{"key":"S0924270800026181_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00199-9"},{"key":"S0924270800026181_ref012","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000120557.83907.A8"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270800026181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T16:38:46Z","timestamp":1556210326000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270800026181\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0924270800026181"],"URL":"https:\/\/doi.org\/10.1111\/j.1601-5215.2011.00620.x","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2011","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}