{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:01:28Z","timestamp":1790974888069,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:p><jats:bold>Authors \u2013\u2002<\/jats:bold>Weinberg SM, Maher BS, Marazita ML<\/jats:p><jats:p><jats:bold>Objective \u2013\u2002<\/jats:bold>To integrate findings from previous cephalometric studies comparing the craniofacial complex of unaffected parents with cleft lip with or without cleft palate (CL\/P) children to controls with no history of the disease.<\/jats:p><jats:p><jats:bold>Design \u2013\u2002<\/jats:bold>Meta\u2010analysis of case\u2010control cephalometric data.<\/jats:p><jats:p><jats:bold>Inclusion criteria \u2013\u2002<\/jats:bold>Studies were selected if the unaffected parents of children with CL\/P were included and were not combined with parents of children with isolated CP; quantitative data were obtained through cephalometry; the cephalometric variables used were not unique to a study; a case\u2010control design was used; and the means and standard deviations for all variables were reported or could be calculated for both the experimental and the control group.<\/jats:p><jats:p><jats:bold>Outcome measure \u2013\u2002<\/jats:bold>Using raw data obtained from nine studies, mean weighted effect sizes with 95% confidence intervals were calculated for 28 cephalometric variables (mothers and fathers combined) or 18 variables (mothers and fathers separately). Heterogeneity statistics for the effect sizes were also calculated.<\/jats:p><jats:p><jats:bold>Results \u2013\u2002<\/jats:bold>In general, unaffected parents of children with CL\/P possessed significantly wider interorbital, nasal cavity and upper facial dimensions, narrower cranial vaults, longer cranial bases, longer and more protrusive mandibles, shorter upper faces and longer lower faces compared with controls. Increased width of the nasal cavity was the most robust finding. Significant effect size heterogeneity was observed in roughly half of the variables examined.<\/jats:p><jats:p><jats:bold>Conclusion \u2013\u2002<\/jats:bold>Unaffected parents of children with CL\/P are characterized by a suite of consistent, yet subtle, craniofacial differences, which could indicate an underlying genetic liability.<\/jats:p>","DOI":"10.1111\/j.1601-6343.2006.00339.x","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T14:39:51Z","timestamp":1137595191000},"page":"18-30","source":"Crossref","is-referenced-by-count":38,"title":["Parental craniofacial morphology in cleft lip with or without cleft palate as determined by cephalometry: a meta\u2010analysis"],"prefix":"10.1111","volume":"9","author":[{"given":"SM","family":"Weinberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BS","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ML","family":"Marazita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.7.2.112"},{"key":"e_1_2_7_3_2","first-page":"318","article-title":"A study of cephalometric features in cleft lip\u2010cleft palate families I: phenotypic heterogeneity and genetic predisposition in parents of sporadic cases","volume":"26","author":"Ward RE","year":"1989","journal-title":"Cleft Palate J"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-4356(98)90498-3"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010106"},{"key":"e_1_2_7_6_2","first-page":"216","article-title":"Incidence of cleft lip, cleft palate, and cleft lip and palate among races: a review","volume":"24","author":"Vanderas AP","year":"1987","journal-title":"Cleft Palate J"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980827)79:1<42::AID-AJMG11>3.0.CO;2-M"},{"key":"e_1_2_7_8_2","volume-title":"Facial Growth","author":"Enlow DH","year":"1990"},{"key":"e_1_2_7_9_2","first-page":"201","volume-title":"Anthropometry of the Head and Face","author":"Hajni\u0161 K","year":"1994"},{"key":"e_1_2_7_10_2","first-page":"293","volume-title":"Forensic Osteology: Advances in the Identification of Human Remains","author":"Gill GW","year":"1998"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420060302"},{"issue":"2","key":"e_1_2_7_12_2","first-page":"187","article-title":"Palatal width growth rates as the genetic determinant of cleft palate induced by vitamin A","author":"Siegel MI","year":"1986","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_7_13_2","first-page":"234","article-title":"Genetic consideration on the dysplasia of the nasopalatal segments as a \u2018Formes Frustes\u2019 radiologically found in parents of cleft children: a preliminary report","volume":"7","author":"Fukuhara T","year":"1962","journal-title":"Jpn J Hum Genet"},{"key":"e_1_2_7_14_2","first-page":"333","article-title":"Possible carrier status of hereditary cleft palate with cleft lip: report of cases","volume":"10","author":"Fukuhara T","year":"1963","journal-title":"Bull Tokyo Med Dent Univ"},{"key":"e_1_2_7_15_2","first-page":"178","volume-title":"The Causes and Natural History of Cleft Lip and Palate","author":"Dixon DA","year":"1966"},{"key":"e_1_2_7_16_2","first-page":"548","article-title":"The radiological appearance of the nasal fossas in the ancestors and immediate relations of subjects with cleft palate. 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