{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:28:25Z","timestamp":1765355305868},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:p><jats:bold>Authors \u2013\u2002<\/jats:bold> Verna C, Hartig LE, Kalia S, Melsen B<\/jats:p><jats:p><jats:bold>Objectives \u2013\u2002<\/jats:bold> To investigate the effect of acute and chronic corticosteroid treatment on orthodontically induced root resorption.<\/jats:p><jats:p><jats:bold>Design \u2013\u2002<\/jats:bold> \u2018Split mouth\u2019 design performing orthodontic tooth movement in 64, 6\u2010month\u2010old male rats divided into three groups: acute (n\u2003=\u200322), chronic (n\u2003=\u200323) and control group (n\u2003=\u200319). Acute and chronic group received corticosteroid treatment (8\u2003mg\/kg\/day) for 3 and 7\u2003weeks, respectively, while no pharmacological treatment was performed in the control group. Performed at the Department of Orthodontics, School of Dentistry, University of Aarhus, Aarhus, Denmark.<\/jats:p><jats:p><jats:bold>Experimental variable \u2013\u2002<\/jats:bold> The upper left first molar was moved mesially for 21\u2003days in all three groups with 25\u2003g of force. Undecalcified histological sections were cut at the coronal and apical level.<\/jats:p><jats:p><jats:bold>Outcome measure \u2013\u2002<\/jats:bold> The number of intersections hitting resorption lacunae (ES), defined as a scalloped surface with or without cementoclasts, over the total number of intersections hitting the root surface (RS) were recorded and expressed as percentage.<\/jats:p><jats:p><jats:bold>Results \u2013\u2002<\/jats:bold> The acute group showed significantly more root resorption at the mesio\u2010coronal level compared with the control and the chronic group.<\/jats:p><jats:p><jats:bold>Conclusion \u2013\u2002<\/jats:bold> This could be ascribed to the lack of balance between blastic activities (inhibited by the drug) and the clastic activities (enhanced or unchanged by drug administration) occurring in the initial phase of drug administration. As a consequence, a careful monitoring of patients undergoing acute corticosteroid treatment is suggested.<\/jats:p>","DOI":"10.1111\/j.1601-6343.2006.00342.x","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T14:39:51Z","timestamp":1137595191000},"page":"57-62","source":"Crossref","is-referenced-by-count":28,"title":["Influence of steroid drugs on orthodontically induced root resorption"],"prefix":"10.1111","volume":"9","author":[{"given":"C","family":"Verna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LE","family":"Hartig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Melsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Dansk Institut for Klinisk Epidemiologi","author":"Dike","year":"1997"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(97)00053-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(05)80253-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(92)70046-D"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2004.00278.x"},{"key":"e_1_2_6_7_2","first-page":"118","article-title":"Orthodontic tooth movement in the prednisolone\u2010treated rat","volume":"70","author":"Ong CK","year":"2000","journal-title":"Angle Orthod"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/19.1.21"},{"key":"e_1_2_6_9_2","first-page":"1070","article-title":"The effect of glucocorticoids on the strength of rat cortical bone","author":"\u00d8rtoft G","year":"1987","journal-title":"Osteoporosis 1987 International Symposium on Osteoporosis"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345920710070101"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/22.4.343"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650020617"},{"key":"e_1_2_6_13_2","first-page":"25","article-title":"Age\u2010related changes of cancelluous and cortical bone histomorphometry in female sprague\u2010dawley rats","volume":"1","author":"Li XJ","year":"1991","journal-title":"Cells Mater"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0307-742X(21)00573-7","article-title":"Glucocorticoid\u2010induced osteoporosis","volume":"12","author":"Gennari C","year":"1986","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199600526-00003"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(91)90029-I"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/22.4.343"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(75)90237-7"},{"key":"e_1_2_6_19_2","first-page":"105","article-title":"The influence of bone turnover on tooth movement in a rat model","volume":"21","author":"Verna C","year":"1999","journal-title":"Eur J Orthod"},{"key":"e_1_2_6_20_2","volume-title":"The Influence of Different Bone Turnover Rates on the Tissue Reactions to Orthodontic Load","author":"Verna C.","year":"1999"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(84)90163-5"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(81)90289-X"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/25.4.359"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(88)90077-7"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00016-1"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1750155"}],"container-title":["Orthodontics &amp; 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